دورية أكاديمية
Role of HLA-G in tumors and upon COVID-19 infection.
| العنوان: | Role of HLA-G in tumors and upon COVID-19 infection. |
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| المؤلفون: | Seliger B; Institute of Translational Immunology, Medical School 'Theodor Fontane', 14770, Brandenburg an der Havel, Germany; Medical Faculty, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany; Fraunhofer Institute for Cell Therapy and Immunology, 04103, Leipzig, Germany. Electronic address: barbara.seliger@uk-halle.de. |
| المصدر: | Human immunology [Hum Immunol] 2024 May; Vol. 85 (3), pp. 110792. Date of Electronic Publication: 2024 Mar 29. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York] Elsevier/North-Holland. |
| مواضيع طبية MeSH: | HLA-G Antigens*/immunology , HLA-G Antigens*/genetics , HLA-G Antigens*/metabolism , COVID-19*/immunology , Neoplasms*/immunology , SARS-CoV-2*/immunology , SARS-CoV-2*/physiology , Tumor Microenvironment*/immunology, Humans ; Killer Cells, Natural/immunology ; Tumor Escape |
| مستخلص: | HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: HLA-G; Immune response; Regulation; Tumor; Virus |
| المشرفين على المادة: | 0 (HLA-G Antigens) |
| تواريخ الأحداث: | Date Created: 20240330 Date Completed: 20240602 Latest Revision: 20240604 |
| رمز التحديث: | 20240604 |
| DOI: | 10.1016/j.humimm.2024.110792 |
| PMID: | 38555250 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-1166 |
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| DOI: | 10.1016/j.humimm.2024.110792 |