دورية أكاديمية
Marrow Fat-Cortical Bone Relationship in β-Thalassemia: A Study Using MRI.
| العنوان: | Marrow Fat-Cortical Bone Relationship in β-Thalassemia: A Study Using MRI. |
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| المؤلفون: | Ismail UN; Makmal Pemprosesan Imej Kefungsian (Functional Image Processing Laboratory), Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bangi, Malaysia., Azlan CA; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Khairullah S; Haematology Unit, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Azman RR; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Omar NF; Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Md Shah MN; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Jackson N; Red Cell Unit, Department of Haematology, University College London Hospital, London, UK., Ng KH; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. |
| المصدر: | Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2024 Mar 31. Date of Electronic Publication: 2024 Mar 31. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9105850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2586 (Electronic) Linking ISSN: 10531807 NLM ISO Abbreviation: J Magn Reson Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken , N.J. : Wiley-Liss Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991- |
| مستخلص: | Background: Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. Purpose: To investigate the relationship between marrow fat and cortical bone thickness in β-thalassemia and to identify key determinants influencing these variables. Study Type: Prospective. Subjects: Thirty-five subjects in four subject groups of increasing disease severity: 6 healthy control (25.0 ± 5.3 years, 2 male), 4 β-thalassemia minor, 13 intermedia, and 12 major (29.1 ± 6.4 years, 15 male). Field Strength/sequence: 3.0 T, 3D fast low angle shot sequence and T Assessment: Analyses on proton density fat fraction (PDFF) and R Statistical Tests: One-way analysis of variance (ANOVA), mixed ANOVA, Pearson correlation and multiple regression. P-values <0.05 were considered significant. Results: Bone marrow PDFF significantly varied between the femur subregions, F(2.89,89.63) = 44.185 and disease severity, F(1,3) = 12.357. A significant interaction between subject groups and femur subregions on bone marrow PDFF was observed, F(8.67,89.63) = 3.723. Notably, a moderate positive correlation was observed between PDFF and CBI (r = 0.33-0.45). Multiple regression models for both PDFF (R 2 = 0.476, F(13,151) = 10.547) and CBI (R 2 = 0.477, F(13,151) = 10.580) were significant. Significant predictors for PDFF were disease severity (β Data Conclusion: This study revealed a positive correlation between bone marrow fat fraction and cortical bone thickness in β-thalassemia with varying disease severity, potentially indicating a complex interplay between bone health and marrow composition. Evidence Level: 2 TECHNICAL EFFICACY: Stage 3. (© 2024 International Society for Magnetic Resonance in Medicine.) |
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| معلومات مُعتمدة: | FP053-2020 Ministry of Higher Education; DOMRSF-2022-04 Universiti Malaya; DIP-2022-023 Centre for Research & Instrumentation, Universiti Kebangsaan Malaysia |
| فهرسة مساهمة: | Keywords: bone; magnetic resonance imaging; marrow adipose tissue; β‐thalassemia |
| تواريخ الأحداث: | Date Created: 20240401 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| DOI: | 10.1002/jmri.29366 |
| PMID: | 38556790 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1522-2586 |
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| DOI: | 10.1002/jmri.29366 |