دورية أكاديمية
Vγ9Vδ2 T-cells Are Potent Inhibitors of SARS-CoV-2 Replication and Represent Effector Phenotypes in Patients With COVID-19.
| العنوان: | Vγ9Vδ2 T-cells Are Potent Inhibitors of SARS-CoV-2 Replication and Represent Effector Phenotypes in Patients With COVID-19. |
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| المؤلفون: | Gay L; Institut de recherche pour le developpement (IRD), Assistance-Publique Hopitaux de Marseille (APHM), Microbes Evolution Phylogénie et Infections (MEPHI), Aix-Marseille University, Marseille, France.; ImCheck Therapeutics, Marseille, France., Rouviere MS; Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Institut Paoli Calmettes, Marseille, France., Mezouar S; Etablissement Français du Sang, Centre National de la Recherche Scientifique, Anthropologie Bio-Culturelle, Droit, Éthique et Santé, 'Biologie des Groupes Sanguins,' Aix-Marseille University, Marseille, France., Richaud M; Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Institut Paoli Calmettes, Marseille, France., Gorvel L; Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Institut Paoli Calmettes, Marseille, France., Foucher E; ImCheck Therapeutics, Marseille, France., La Scola B; Institut de recherche pour le developpement (IRD), Assistance-Publique Hopitaux de Marseille (APHM), Microbes Evolution Phylogénie et Infections (MEPHI), Aix-Marseille University, Marseille, France., Menard A; Unité COVID-Long, Service de Médecine Interne, Centre Hospitalo-Universitaire Nord (CHU NORD), Assistance-Publique Hopitaux de Marseille (APHM), Marseille, France., Allardet-Servent J; Service de Réanimation, Hôpital Européen, Marseille, France., Halfon P; Département de Médecine Interne et Maladies Infectieuses, Hôpital Européen-Laboratoire Alphabio-Biogroup, Marseille, France., Frohna P; ImCheck Therapeutics, Marseille, France., Cano C; ImCheck Therapeutics, Marseille, France., Mege JL; Institut de recherche pour le developpement (IRD), Assistance-Publique Hopitaux de Marseille (APHM), Microbes Evolution Phylogénie et Infections (MEPHI), Aix-Marseille University, Marseille, France.; Assistance-Publique Hopitaux de Marseille (APHM), Hôpital de la Conception, Laboratoire d'Immunologie, Aix-Marseille University, Marseille, France., Olive D; Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Institut Paoli Calmettes, Marseille, France. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Jun 14; Vol. 229 (6), pp. 1759-1769. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | COVID-19*/immunology , COVID-19*/virology , Virus Replication*/drug effects , SARS-CoV-2*/immunology , Butyrophilins*/metabolism, Humans ; Male ; Female ; Middle Aged ; Adult ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; T-Lymphocytes/immunology ; Lung/virology ; Lung/immunology ; Lung/pathology ; Phenotype ; Interferon-gamma/metabolism ; Interferon-gamma/immunology ; Macrophages/immunology ; Macrophages/virology ; Antigens, CD |
| مستخلص: | Vγ9Vδ2 T cells play a key role in the innate immune response to viral infections through butyrophilin 3A (BTN3A). Here, we report blood Vγ9Vδ2 T cells decreased in clinically mild COVID-19 compared to healthy volunteers, and this was maintained up to 28 days and in the recovery period. Terminally differentiated Vγ9Vδ2 T cells tended to be enriched on the day of diagnosis, 28 days after, and during the recovery period. These cells showed cytotoxic and inflammatory activities following anti-BTN3A activation. BTN3A upregulation and Vγ9Vδ2 T-cell infiltration were observed in a lung biopsy from a fatal SARS-CoV-2 infection. In vitro, SARS-CoV-2 infection increased BTN3A expression in macrophages and lung cells that enhanced the anti-SARS-CoV-2 Vγ9Vδ2 T-cell cytotoxicity and interferon-γ and tumor necrosis factor-α. Increasing concentrations of anti-BTN3A lead to viral replication inhibition. Altogether, we report Vγ9Vδ2 T cells are important in the immune response against SARS-CoV-2 infection and activation by anti-BTN3A antibody may enhance their response. Clinical Trials Registration. NCT04816760. Competing Interests: Potential conflicts of interest. D. O. is cofounder and shareholder of ImCheck Therapeutics, Emergence Therapeutics, Alderaan Biotechnology, and Stealth IO. E. F., L. M., P. F., and C. C. are employees and shareholders of ImCheck Therapeutics. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| معلومات مُعتمدة: | Agence Nationale de la Recherche; Canceropôle Provence-Alpes-Côte d'Azur |
| فهرسة مساهمة: | Keywords: BTN3A; SARS-CoV-2; Vγ9Vδ2 T cells; antiviral immunity; immunotherapy |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04816760 |
| المشرفين على المادة: | 0 (Butyrophilins) 0 (BTN3A1 protein, human) 0 (Receptors, Antigen, T-Cell, gamma-delta) 82115-62-6 (Interferon-gamma) 0 (Antigens, CD) |
| تواريخ الأحداث: | Date Created: 20240401 Date Completed: 20240613 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1093/infdis/jiae169 |
| PMID: | 38557809 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae169 |