دورية أكاديمية
أعرض في EDS

First imported case of Candida auris infection in Milan, Italy: genomic characterisation.

التفاصيل البيبلوغرافية
العنوان: First imported case of Candida auris infection in Milan, Italy: genomic characterisation.
المؤلفون: Rimoldi SG; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Nodari R; Department of Biomedical and Clinical Sciences, Romeo ed Enrica Invernizzi Paediatric Research Centre, University of Milan, Milan, Italy., Rizzo A; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Tamoni A; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Longobardi C; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Pagani C; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Grosso S; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Salari F; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Galimberti L; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy., Olivieri P; Medical Direction Unit, ASST Fatebenefratelli Sacco, Milan, Italy., Rizzardini G; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy., Catena E; Anestesiology Unit, ASST Fatebenefratelli Sacco, Milan, Italy., Antinori S; Dipartimento di Scienze Biomediche e Cliniche, ASST Fatebenefratelli Sacco, Università di Milano, Via Giovanni Battista Grassi n° 74, 20157, Milan, Italy. spinello.antinori@unimi.it.; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy. spinello.antinori@unimi.it., Comandatore F; Department of Biomedical and Clinical Sciences, Romeo ed Enrica Invernizzi Paediatric Research Centre, University of Milan, Milan, Italy., Castelli A; Anestesiology Unit, ASST Fatebenefratelli Sacco, Milan, Italy., Gismondo MR; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, ASST Fatebenefratelli Sacco, Università di Milano, Via Giovanni Battista Grassi n° 74, 20157, Milan, Italy.
المصدر: Infection [Infection] 2024 Aug; Vol. 52 (4), pp. 1633-1638. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : Heidelberg : Springer Heidelberg
Original Publication: München, Verlagsgesellschaft Otto Spatz.
مواضيع طبية MeSH: Phylogeny* , Candidiasis*/microbiology , Candidiasis*/drug therapy , Candidiasis*/diagnosis , Antifungal Agents*/therapeutic use , Candida auris*/genetics, Humans ; Male ; Italy ; Aged, 80 and over ; Greece ; Whole Genome Sequencing ; Communicable Diseases, Imported/microbiology ; Communicable Diseases, Imported/diagnosis ; Fatal Outcome ; Microbial Sensitivity Tests ; Candidiasis, Invasive
مستخلص: Purpose: Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance.
Case Presentation: On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain.
Conclusion: Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Candida auris; Italy; Multi-Drug-Resistance-Organism; Whole-Genome-Sequencing; Yeast
المشرفين على المادة: 0 (Antifungal Agents)
SCR Disease Name: Candida auris infection
تواريخ الأحداث: Date Created: 20240401 Date Completed: 20240730 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC11289026
DOI: 10.1007/s15010-024-02232-x
PMID: 38557967
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-0973
DOI:10.1007/s15010-024-02232-x