دورية أكاديمية
أعرض في EDS

Pediatric poisoning management: How clinical practice can benefit from forensic approach.

التفاصيل البيبلوغرافية
العنوان: Pediatric poisoning management: How clinical practice can benefit from forensic approach.
المؤلفون: Basilicata P; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Marisei M; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Guadagni R; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Sibilio M; U.O.C. Pediatria 1 - A.O.R.N. 'Santobono-Pausilipon', Naples, Italy., Niola M; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Pieri M; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
المصدر: Journal of forensic sciences [J Forensic Sci] 2024 Jul; Vol. 69 (4), pp. 1501-1507. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Pub Country of Publication: United States NLM ID: 0375370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-4029 (Electronic) Linking ISSN: 00221198 NLM ISO Abbreviation: J Forensic Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : Malden, MA : Blackwell Pub.
Original Publication: [Chicago, Ill.] : Callaghan and Co., 1956-
مواضيع طبية MeSH: Forensic Toxicology* , Poisoning*/diagnosis , Poisoning*/therapy , Buprenorphine*/poisoning, Humans ; Narcotics/poisoning ; Narcotics/analysis ; Algorithms ; Specimen Handling ; Child, Preschool ; Male ; Child ; Analgesics, Opioid/poisoning ; Medical History Taking ; Female
مستخلص: Pediatric population represents the most vulnerable and at risk for unintentional poisoning, with children younger than 6 years old accounting for nearly half of poison exposures. Poisoning is a time-dependent emergency. The need to reach a scientific agreement on diagnostic protocol and treatment seems to be crucial to reduce morbidity and mortality. Starting from a buprenorphine pediatric intoxication case, this article highlights the limits and pitfalls of the traditional diagnostic approach. Diagnosis of drug intoxication was achieved after several days when an in-depth diagnostic investigation became necessary and complete forensic toxicological analyses were performed. Results evidenced an alarming lack of an unequivocal diagnostic protocol in case of suspect intoxication in structures not provided with a forensic toxicological service/unit. Collection of biological specimens according to forensic protocols at hospitalization plays a paramount role in the definitive diagnosis of intoxication. A diagnostic algorithm that focuses on medical history and biological specimen collection timing is herein proposed, in order to unify emergency approaches to the suspected poisoned child.
(© 2024 American Academy of Forensic Sciences.)
References: WHO World Health Statistics. Monitoring health for the SDGs. 2023 Sustainable Development Goals 2023. Accessed October 03, 2023. Available from: https://www.who.int/publications/i/item/9789240074323.
Madden MA. Pediatric toxicology: emerging trends. J Pediatr Intensive Care. 2015;4:103–110. https://doi.org/10.1055/s‐0035‐1556753.
National Capital Poison Center. 2001. Accessed October 03, 2023. Available from: https://www.poison.org/poison‐statistics‐national.
WHO, Peden M, Oyegbite K, Ozanne‐Smith J, Hyder AA, Branche C, et al. (Eds.)World report on child injury prevention. 2008 Accessed October 03, 2023. Available from: https://apps.who.int/iris/handle/10665/43851.
Taft C, Paul H, Consunji R, Miller T. Childhood unintentional injury worldwide: meeting the challenge. Washington, DC: Safekids Worldwide; 2002 Accessed October 03, 2023. Available from: http://www.safekids.org/pdf/WW‐Study‐Ltr.pdf.
Avau B, Borra V, Vanhove AC, Vandekerckhove P, De Paepe P, De Buck E. First aid interventions by laypeople for acute oral poisoning. Cochrane Database Syst Rev. 2018;12:CD013230. https://doi.org/10.1002/14651858.CD013230.
Calello DP, Henretig FM. Pediatric toxicology: specialized approach to the poisoned child. Emerg Med Clin North Am. 2014;32:29–52. https://doi.org/10.1016/j.emc.2013.09.008.
Osterhoudt KC. The lexiconography of toxicology. J Med Toxicol. 2006;2:1–3. https://doi.org/10.1007/BF03161004.
Bacha T, Tilahun B. A cross‐sectional study of children with acute poisoning: a three‐year retrospective analysis. World J Emerg Med. 2015;6(4):265–269. https://doi.org/10.5847/wjem.j.1920‐8642.2015.04.003.
Madden MA. Pediatric poisonings: recognition, assessment, and management. Crit Care Nurs Clin North Am. 2005;17:395–404. https://doi.org/10.1016/j.ccell.2005.07.004.
Hauptman M, Woolf AD. Childhood ingestions of environmental toxins: what are the risks? Pediatr Ann. 2017;46:e466–e471. https://doi.org/10.3928/19382359‐20171116‐01.
Funk RS, Brown JT, Abdel‐Rahman SM. Pediatric pharmacokinetics: human development and drug disposition. Pediatr Clin N Am. 2012;59:1001–1016. https://doi.org/10.1016/j.pcl.2012.07.003.
Gummin DD, Mowry JB, Spyker DA, Brooks DE, Beuhler MC, Rivers LJ, et al. 2018 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 36th annual report. Clin Toxicol (Phila). 2019;57:1220–1413. https://doi.org/10.1080/15563650.2019.1677022.
Bond GR, Woodward RW, Ho M. The growing impact of pediatric pharmaceutical poisoning. J Pediatr. 2012;160:265–270.e1. https://doi.org/10.1016/j.jpeds.2011.07.042.
Gaither JR, Shabanova V, Leventhal JM. US national trends in pediatric deaths from prescription and illicit opioids, 1999‐2016. JAMA Netw Open. 2018;1:e186558. https://doi.org/10.1001/jamanetworkopen.2018.6558.
Ross JA, Eldridge DL. Pediatric toxicology. Emerg Med Clin North Am. 2022;40:237–250. https://doi.org/10.1016/j.emc.2022.01.004.
Elsohly MA, Gul W, Feng S, Murphy TP. Hydrolysis of conjugated metabolites of buprenorphine II. The quantitative enzymatic hydrolysis of norbuprenorphine‐3‐β‐d‐glucuronide in human urine. J Anal Toxicol. 2005;29:570–573. https://doi.org/10.1093/jat/29.6.570.
Seldén T, Roman M, Druid H, Kronstrand R. LC‐MS‐MS analysis of buprenorphine and norbuprenorphine in whole blood from suspected drug users. Forensic Sci Int. 2011;209:113–119. https://doi.org/10.1016/j.forsciint.2011.01.011.
Hayes BD, Klein‐Schwartz W, Doyon S. Toxicity of buprenorphine overdoses in children. Pediatr Dent. 2008;121:e782–e786. https://doi.org/10.1542/peds.2007‐1774.
de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet. 1999;37:485–505. https://doi.org/10.2165/00003088‐199937060‐00004.
Boyer EW, McCance‐Katz EF, Marcus S. Methadone and buprenorphine toxicity in children. Am J Addict. 2010;19:89–95. https://doi.org/10.1111/j.1521‐0391.2009.00002.x.
Geib AJ, Babu K, Ewald MB, Boyer EW. Adverse effects in children after unintentional buprenorphine exposure. Pediatrics. 2006;118:1746–1751. https://doi.org/10.1542/peds.2006‐0948.
Lo Re M, Chaplin M, Aronow B, Modesto‐Lowe V. Buprenorphine overdose in young children: an underappreciated risk. Clin Pediatr (Phila). 2019;58:613–617. https://doi.org/10.1177/0009922819829038.
Franchitto N. Buprenorphine poisoning in children: a 10‐year experience of Marseille poison center. Fundam Clin Pharmacol. 2020;34:263–264. https://doi.org/10.1111/fcp.12547.
von Fabeck K, Boulamery A, Glaizal M, de Haro L, Simon N. Buprenorphine poisoning in children: a 10‐year‐experience of Marseille poison center. Fundam Clin Pharmacol. 2020;34(2):265–269. https://doi.org/10.1111/fcp.12518.
فهرسة مساهمة: Keywords: biological specimen; diagnostic algorithm; diagnostic workup; drug intoxication; pediatric accidental poisoning; toxicology
المشرفين على المادة: 40D3SCR4GZ (Buprenorphine)
0 (Narcotics)
0 (Analgesics, Opioid)
تواريخ الأحداث: Date Created: 20240401 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1111/1556-4029.15517
PMID: 38558455
قاعدة البيانات: MEDLINE
الوصف
تدمد:1556-4029
DOI:10.1111/1556-4029.15517