Social state gates vision using three circuit mechanisms in Drosophila .
| العنوان: | Social state gates vision using three circuit mechanisms in Drosophila . |
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| المؤلفون: | Schretter CE; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Sten TH; Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, USA., Klapoetke N; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Shao M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Nern A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Dreher M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Bushey D; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Robie AA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Taylor AL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Branson KM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Otopalik A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA., Ruta V; Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, USA., Rubin GM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 17. Date of Electronic Publication: 2024 Mar 17. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well-studied. Yet, much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviors, flies need to focus on nearby flies. Here, we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identified three state-dependent circuit motifs poised to selectively amplify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioral and neurophysiological analyses, we show that each of these circuit motifs function during female aggression. We reveal that features of this same switch operate in males during courtship pursuit, suggesting that disparate social behaviors may share circuit mechanisms. Our work provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals. |
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| معلومات مُعتمدة: | R35 NS111611 United States NS NINDS NIH HHS |
| تواريخ الأحداث: | Date Created: 20240401 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC10979952 |
| DOI: | 10.1101/2024.03.15.585289 |
| PMID: | 38559111 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2024.03.15.585289 |
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