دورية أكاديمية
Comparison of trigeminal lateralization with differing stimulants.
| العنوان: | Comparison of trigeminal lateralization with differing stimulants. |
|---|---|
| المؤلفون: | Chen T; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Poupore NS; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Shih MC; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Edwards TS; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Nguyen SA; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Soler ZM; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA., Schlosser RJ; Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA. |
| المصدر: | World journal of otorhinolaryngology - head and neck surgery [World J Otorhinolaryngol Head Neck Surg] 2023 Aug 03; Vol. 10 (1), pp. 66-69. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Ltd on behalf of Chinese Medical Association Country of Publication: United States NLM ID: 101690857 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-1081 (Electronic) Linking ISSN: 20958811 NLM ISO Abbreviation: World J Otorhinolaryngol Head Neck Surg Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Hoboken, NJ] : John Wiley & Sons, Ltd on behalf of Chinese Medical Association Original Publication: [Beijing] : Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd., [2015]- |
| مستخلص: | Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory perception. It is unclear whether trigeminal sensitivity is similar across different transient receptor potential (TRP) receptors or if dysfunction of different receptors results in differing patient symptoms. Therefore, a prospective cohort study was conducted, consisting of trigeminal lateralization testing with three different stimulants (eucalyptol, isothiocyanate, acetic acid), olfaction testing with Sniffin' Sticks, and measurement of various patient-reported outcome measures (PROMs). A total of 50 participants were enrolled across the olfactory spectrum. Mean TDI score was 27.1 ± 8.3 (range 7.0-39.5) with 38% normosmic and 62% dysosmic. Mean trigeminal lateralization scores out of 20 in the overall cohort were 16.18 (2.78) for eucalyptol, 14.94 (3.49) for mustard oil, and 15.28 (3.68) for vinegar. Eucalyptol showed a significant correlation with threshold scores of Sniffin' Sticks. A significant correlation was found between acetic acid and various PROMs. None of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to age. The lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other receptors. Additional investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings. Competing Interests: The authors declare no conflict of interest. Professor Shaun A. Nguyen is a member of World Journal of Otorhinolaryngology – Head & Neck Surgery (WJOHNS) editorial board and is not involved in the peer review process of this article. [Correction added on 10 November 2023, after first online publication: The section CONFLICT OF INTEREST STATEMENT was revised.] (© 2023 The Authors. World Journal of Otorhinolaryngology ‐ Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.) |
| References: | Laryngoscope. 2016 May;126(5):E174-8. (PMID: 26926075) Laryngoscope. 2017 Jun;127(6):1263-1267. (PMID: 28224626) J Neurol. 2020 Jan;267(1):138-143. (PMID: 31586261) Eur Arch Otorhinolaryngol. 2018 Jul;275(7):1783-1788. (PMID: 29744638) Handb Clin Neurol. 2019;164:119-134. (PMID: 31604542) Eur J Pain. 2017 Jan;21(1):92-100. (PMID: 27320501) Toxicol Lett. 2003 Apr 11;140-141:273-80. (PMID: 12676474) Neuroscience. 2011 Aug 25;189:377-83. (PMID: 21575683) |
| فهرسة مساهمة: | Keywords: TRP receptor; chemosensory; olfaction; trigeminal |
| تواريخ الأحداث: | Date Created: 20240401 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC10979039 |
| DOI: | 10.1002/wjo2.116 |
| PMID: | 38560039 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2589-1081 |
|---|---|
| DOI: | 10.1002/wjo2.116 |