دورية أكاديمية
Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases.
| العنوان: | Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases. |
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| المؤلفون: | Gao H; Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, 314001, China.; Department of Pharmacy, The General Hospital of Xinjiang Military Region, Urumqi, 830000, China., Zhang J; Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, 314001, China., Kleijn TG; Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, 314001, China.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands.; Department of Pathology, Laboratory of Experimental Oncology, Erasmus MC, Rotterdam, 3015 GD, The Netherlands., Wu Z; Department of Pharmacy, Jiaxing Maternal and Child Health Care Hospital, Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China., Liu B; Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, 314001, China.; Qinghai Enlu Biotechnology Co., Ltd., Haidong, 810700, China., Ma Y; Qinghai Enlu Biotechnology Co., Ltd., Haidong, 810700, China., Ding B; Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, 314001, China., Yin D; Department of Pharmacy, The General Hospital of Xinjiang Military Region, Urumqi, 830000, China. |
| المصدر: | Oncology research [Oncol Res] 2024 Mar 20; Vol. 32 (4), pp. 769-784. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Henderson, NV : Tech Science Press Original Publication: New York : Pergamon Press, c1992- |
| مواضيع طبية MeSH: | Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Antineoplastic Agents*/therapeutic use , Bone Neoplasms*/drug therapy , Poloxalene*, Humans ; Female ; Micelles ; Ligands ; Quality of Life ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Polymers/chemistry ; Polymers/therapeutic use ; Drug Delivery Systems ; Alendronate/pharmacology ; Alendronate/chemistry ; Alendronate/therapeutic use ; Drug Carriers/chemistry ; Drug Carriers/therapeutic use |
| مستخلص: | Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The DOX-loaded polymeric micelles were spherical, 123 nm in diameter on average, and exhibited a narrow size distribution. The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release. The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells. Rapid binding of the micelles to hydroxyapatite (HA) microparticles indicated their high affinity for bone. P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model. In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity. In conclusion, our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis. Competing Interests: The authors declare that they have no conflicts of interest to report regarding the present study. (© 2024 Gao et al.) |
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| فهرسة مساهمة: | Keywords: Breast cancer with bone metastasis; Nanoparticulate drug delivery system; Pluronic micelles; Targeted nanotherapeutics; Therapeutic efficacy |
| المشرفين على المادة: | 0 (Micelles) 2E9U4Y94DB (pluronic block copolymer P123) 0 (Ligands) 80168379AG (Doxorubicin) 0 (Polymers) 0 (Antineoplastic Agents) X1J18R4W8P (Alendronate) 0 (Drug Carriers) 9003-11-6 (Poloxalene) |
| تواريخ الأحداث: | Date Created: 20240401 Date Completed: 20240403 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC10972726 |
| DOI: | 10.32604/or.2023.044276 |
| PMID: | 38560569 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1555-3906 |
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| DOI: | 10.32604/or.2023.044276 |