دورية أكاديمية
أعرض في EDS

Pseudomonas putida infection induces immune-antioxidant, hepato-renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel.

التفاصيل البيبلوغرافية
العنوان: Pseudomonas putida infection induces immune-antioxidant, hepato-renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel.
المؤلفون: Rahman ANA; Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt. afne56@gmail.com., Mahboub HH; Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt. hhhmb@yahoo.com., Elshopakey GE; Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, PO Box 35516, Mansoura, Dakahlia, Egypt., Darwish MIM; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, PO Box 44511, Sharkia, Egypt., Gharib HSA; Department of Behaviour and Management of Animal, Poultry, and Aquatics, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt., Shaalan M; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, PO Box 12211, Giza, Egypt. mohamedibrahim@cu.edu.eg.; Polymer Institute, Slovak academy of sciences, Dúbravská cesta 9, 845 41, Bratislava, Slovakia. mohamedibrahim@cu.edu.eg., Fahmy EM; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt., Abdel-Ghany HM; Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt., Ismail SH; Faculty of Nanotechnology for Postgraduate Studies, Cairo University, Sheikh Zayed Branch Campus, PO Box 12588, Sheikh Zayed City, Giza, Egypt., Elsheshtawy HM; Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Suez Canal University, PO Box 41522, Ismailia, Egypt.
المصدر: BMC veterinary research [BMC Vet Res] 2024 Apr 01; Vol. 20 (1), pp. 127. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2005-
مواضيع طبية MeSH: Pseudomonas putida* , Cichlids* , Fish Diseases*/drug therapy , Fish Diseases*/microbiology , Polyethylene Glycols* , Polyethyleneimine* , Titanium*, Animals ; Antioxidants ; Nanogels ; Diet ; Dietary Supplements ; Animal Feed/analysis
مستخلص: Background: Pseudomonas putida is a pathogenic bacterium that induces great losses in fishes, including Nile tilapia (Oreochromis niloticus). Currently, the application of nanomaterials in aquaculture practices has gained more success as it endows promising results in therapies compared to traditional protocols.
Objective: Therefore, the current perspective is considered the first report to assess the anti-bacterial efficacy of titanium dioxide nanogel (TDNG) against Pseudomonas putida (P. putida) in Nile tilapia.
Methods: The fish (n = 200; average body weight: 47.50±1.32 g) were allocated into four random groups (control, TDNG, P. putida, and TDNG + P. putida), where 0.9 mg/L of TDNG was applied as bath treatment for ten days.
Results: Outcomes revealed that P. putida infection caused ethological alterations (surfacing, abnormal movement, and aggression) and depression of immune-antioxidant variables (complement 3, lysozyme activity, total antioxidant capacity, superoxide dismutase, and reduced glutathione content). Additionally, a substantial elevation in hepatorenal biomarkers (aspartate and alanine aminotransferases and creatinine) with clear histopathological changes and immuno-histochemical alterations (very weak BCL-2 and potent caspase-3 immuno-expressions) were seen. Surprisingly, treating P. putida-infected fish with TDNG improved these variables and obvious restoration of the tissue architectures.
Conclusion: Overall, this report encompasses the key role of TDNG as an anti-bacterial agent for controlling P. putida infection and improving the health status of Nile tilapia.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Pseudomonas putida; Bacterial infection; Health status; Immune response; Nile tilapia; Titanium dioxide nanogel
المشرفين على المادة: 0 (Antioxidants)
15FIX9V2JP (titanium dioxide)
0 (polyethylene glycol polyethyleneimine nanogel)
0 (Nanogels)
3WJQ0SDW1A (Polyethylene Glycols)
9002-98-6 (Polyethyleneimine)
D1JT611TNE (Titanium)
تواريخ الأحداث: Date Created: 20240402 Date Completed: 20240403 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC10983678
DOI: 10.1186/s12917-024-03972-6
PMID: 38561720
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-6148
DOI:10.1186/s12917-024-03972-6