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Factors associated with pathologic myopia onset and progression: A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Factors associated with pathologic myopia onset and progression: A systematic review and meta-analysis.
المؤلفون: Yii F; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Curle Ophthalmology Laboratory, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Nguyen L; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Strang N; Department of Vision Sciences, Glasgow Caledonian University, Glasgow, UK., Bernabeu MO; Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.; The Bayes Centre, The University of Edinburgh, Edinburgh, UK., Tatham AJ; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Princess Alexandra Eye Pavilion, NHS Lothian, Edinburgh, UK., MacGillivray T; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Curle Ophthalmology Laboratory, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Dhillon B; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Curle Ophthalmology Laboratory, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.; Princess Alexandra Eye Pavilion, NHS Lothian, Edinburgh, UK.
المصدر: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) [Ophthalmic Physiol Opt] 2024 Jul; Vol. 44 (5), pp. 963-976. Date of Electronic Publication: 2024 Apr 02.
نوع المنشور: Journal Article; Systematic Review; Meta-Analysis; Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishers Country of Publication: England NLM ID: 8208839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-1313 (Electronic) Linking ISSN: 02755408 NLM ISO Abbreviation: Ophthalmic Physiol Opt Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Oxford : Blackwell Publishers
Original Publication: Oxford ; New York : Pergamon Press, c1981-
مواضيع طبية MeSH: Myopia, Degenerative*/physiopathology , Myopia, Degenerative*/epidemiology , Myopia, Degenerative*/diagnosis , Disease Progression*, Humans ; Risk Factors ; Refraction, Ocular/physiology
مستخلص: Purpose: To synthesise evidence across studies on factors associated with pathologic myopia (PM) onset and progression based on the META-analysis for Pathologic Myopia (META-PM) classification framework.
Methods: Findings from six longitudinal studies (5-18 years) were narratively synthesised and meta-analysed, using odds ratio (OR) as the common measure of association. All studies adjusted for baseline myopia, age and sex at a minimum. The quality of evidence was rated using the Grades of Recommendation, Assessment, Development and Evaluation framework.
Results: Five out of six studies were conducted in Asia. There was inconclusive evidence of an independent effect (or lack thereof) of ethnicity and sex on PM onset/progression. The odds of PM onset increased with greater axial length (pooled OR: 2.03; 95% CI: 1.71-2.40; p < 0.001), older age (pooled OR: 1.07; 1.05-1.09; p < 0.001) and more negative spherical equivalent refraction, SER (OR: 0.77; 0.68-0.87; p < 0.001), all of which were supported by an acceptable level of evidence. Fundus tessellation was found to independently increase the odds of PM onset in a population-based study (OR: 3.02; 2.58-3.53; p < 0.001), although this was only supported by weak evidence. There was acceptable evidence that greater axial length (pooled OR: 1.23; 1.09-1.39; p < 0.001), more negative SER (pooled OR: 0.87; 0.83-0.92; p < 0.001) and higher education level (pooled OR: 3.17; 1.36-7.35; p < 0.01) increased the odds of PM progression. Other baseline factors found to be associated with PM progression but currently supported by weak evidence included age (pooled OR: 1.01), severity of myopic maculopathy (OR: 3.61), intraocular pressure (OR: 1.62) and hypertension (OR: 0.21).
Conclusions: Most PM risk/prognostic factors are not supported by an adequate evidence base at present (an indication that PM remains understudied). Current factors for which an acceptable level of evidence exists (limited in number) are unmodifiable in adults and lack personalised information. More longitudinal studies focusing on uncovering modifiable factors and imaging biomarkers are warranted.
(© 2024 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.)
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معلومات مُعتمدة: MR/N013166/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: META‐PM; epidemiology; longitudinal; pathologic myopia; prognostic factors; risk factors
تواريخ الأحداث: Date Created: 20240402 Date Completed: 20240610 Latest Revision: 20240610
رمز التحديث: 20240611
DOI: 10.1111/opo.13312
PMID: 38563652
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-1313
DOI:10.1111/opo.13312