دورية أكاديمية
Impact of scatter correction on personalized dosimetry in selective internal radiotherapy using 166 Ho-PLLA: a single-center study including Monte-Carlo simulation, phantom and patient imaging.
| العنوان: | Impact of scatter correction on personalized dosimetry in selective internal radiotherapy using 166 Ho-PLLA: a single-center study including Monte-Carlo simulation, phantom and patient imaging. |
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| المؤلفون: | Collette B; Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium. benoit.collette@hubruxelles.be.; Laboratory of Image Synthesis and Analysis, Brussels School of Engineering, Université Libre de Bruxelles (ULB), Brussels, Belgium. benoit.collette@hubruxelles.be., Mannie-Corbisier M; Department of Nuclear Metrology, Brussels School of Engineering, Université Libre de Bruxelles (ULB), Brussels, Belgium., Bucalau AM; Department of Gastroenterolgy, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium., Pauly N; Department of Nuclear Metrology, Brussels School of Engineering, Université Libre de Bruxelles (ULB), Brussels, Belgium., Verset G; Department of Gastroenterolgy, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium., Moreno-Reyes R; Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium., Flamen P; Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium., Trotta N; Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070, Brussels, Belgium. |
| المصدر: | EJNMMI physics [EJNMMI Phys] 2024 Apr 02; Vol. 11 (1), pp. 33. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag, GmbH Country of Publication: Germany NLM ID: 101658952 Publication Model: Electronic Cited Medium: Print ISSN: 2197-7364 (Print) Linking ISSN: 21977364 NLM ISO Abbreviation: EJNMMI Phys Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg, Germany : Springer-Verlag, GmbH, [2014]- |
| مستخلص: | Background: Developments in transarterial radioembolization led to the conception of new microspheres loaded with holmium-166 ( 166 Ho). However, due to the complexity of the scatter components in 166 Ho single photon emission computed tomography (SPECT), questions about image quality and dosimetry are emerging. The aims of this work are to investigate the scatter components and correction methods to propose a suitable solution, and to evaluate the impact on image quality and dosimetry including Monte-Carlo (MC) simulations, phantom, and patient data. Methods: Dual energy window (DEW) and triple energy window (TEW) methods were investigated for scatter correction purposes and compared using Contrast Recovery Coefficients (CRC) and Contrast to Noise Ratios (CNR). First, MC simulations were carried out to assess all the scatter components in the energy windows used, also to confirm the choice of the parameter needed for the DEW method. Then, MC simulations of acquisitions of a Jaszczak phantom were conducted with conditions mimicking an ideal scatter correction. These simulated projections can be reconstructed and compared with real acquisitions corrected by both methods and then reconstructed. Finally, both methods were applied on patient data and their impact on personalized dosimetry was evaluated. Results: MC simulations confirmed the use of k = 1 for the DEW method. These simulations also confirmed the complexity of scatter components in the main energy window used with a high energy gamma rays component of about half of the total counts detected, together with a negligible X rays component and a negligible presence of fluorescence. CRC and CNR analyses, realized on simulated scatter-free projections of the phantom and on scatter corrected acquisitions of the same phantom, suggested an increased efficiency of the TEW method, even at the price of higher level of noise. Finally, these methods, applied on patient data, showed significant differences in terms of non-tumoral liver absorbed dose, non-tumoral liver fraction under 50 Gy, tumor absorbed dose, and tumor fraction above 150 Gy. Conclusions: This study demonstrated the impact of scatter correction on personalized dosimetry on patient data. The use of a TEW method is proposed for scatter correction in 166 Ho SPECT imaging. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Holmium-166; Monte-Carlo; Personalized dosimetry; Scatter correction; Selective internal radiotherapy; Transarterial radioembolization |
| تواريخ الأحداث: | Date Created: 20240402 Latest Revision: 20240405 |
| رمز التحديث: | 20240405 |
| مُعرف محوري في PubMed: | PMC10987418 |
| DOI: | 10.1186/s40658-024-00639-x |
| PMID: | 38564100 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2197-7364 |
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| DOI: | 10.1186/s40658-024-00639-x |