دورية أكاديمية
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.
العنوان: | Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. |
---|---|
المؤلفون: | Pecci F; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Nakazawa S; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Harada G; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York., Lee JK; Foundation Medicine, Cambridge, Massachusetts., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Barrichello A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Vaz VR; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Lamberti G; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Di Federico A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gandhi MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gazgalis D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Feng WW; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Jiang J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Baldacci S; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Locquet MA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gottlieb FH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Chen MF; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York., Lee E; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Haradon D; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Smokovich A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Voligny E; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Nguyen T; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Goel VK; Turning Point Therapeutics, Bristol Myers Squibb Company, San Diego, California., Zimmerman Z; Turning Point Therapeutics, Bristol Myers Squibb Company, San Diego, California., Atwal S; Turning Point Therapeutics, Bristol Myers Squibb Company, San Diego, California., Wang X; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Bahcall M; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Heist RS; Massachusetts General Hospital, Boston, Massachusetts., Iqbal S; The Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts., Gandhi N; Caris Life Sciences, Phoenix, Arizona., Elliott A; Caris Life Sciences, Phoenix, Arizona., Vanderwalde AM; Caris Life Sciences, Phoenix, Arizona., Ma PC; Penn State Cancer Institute, Penn State College of Medicine, Penn State University, Hershey, Pennsylvania., Halmos B; Montefiore Einstein Cancer Center, Bronx, New York., Liu SV; Georgetown University, Washington, DC., Che J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Schrock AB; Foundation Medicine, Cambridge, Massachusetts., Drilon A; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. |
المصدر: | Cancer discovery [Cancer Discov] 2024 Aug 02; Vol. 14 (8), pp. 1440-1456. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research |
مواضيع طبية MeSH: | Proto-Oncogene Proteins c-met*/genetics , Proto-Oncogene Proteins c-met*/antagonists & inhibitors , Lung Neoplasms*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Point Mutation*, Humans ; Animals ; Mice ; Cell Line, Tumor |
مستخلص: | Activating point mutations in the MET tyrosine kinase domain (TKD) are oncogenic in a subset of papillary renal cell carcinomas. Here, using comprehensive genomic profiling among >600,000 patients, we identify activating MET TKD point mutations as putative oncogenic driver across diverse cancers, with a frequency of ∼0.5%. The most common mutations in the MET TKD defined as oncogenic or likely oncogenic according to OncoKB resulted in amino acid substitutions at positions H1094, L1195, F1200, D1228, Y1230, M1250, and others. Preclinical modeling of these alterations confirmed their oncogenic potential and also demonstrated differential patterns of sensitivity to type I and type II MET inhibitors. Two patients with metastatic lung adenocarcinoma harboring MET TKD mutations (H1094Y, F1200I) and no other known oncogenic drivers achieved confirmed partial responses to a type I MET inhibitor. Activating MET TKD mutations occur in multiple malignancies and may confer clinical sensitivity to currently available MET inhibitors. Significance: The identification of targetable genomic subsets of cancer has revolutionized precision oncology and offers patients treatments with more selective and effective agents. Here, we demonstrate that activating, oncogenic MET tyrosine kinase domain mutations are found across a diversity of cancer types and are responsive to MET tyrosine kinase inhibitors. (©2024 The Authors; Published by the American Association for Cancer Research.) |
References: | JAMA Oncol. 2016 Mar;2(3):313-20. (PMID: 26720421) N Engl J Med. 2016 Jan 14;374(2):135-45. (PMID: 26536169) N Engl J Med. 2020 Sep 3;383(10):944-957. (PMID: 32877583) J Exp Clin Cancer Res. 2019 Jun 20;38(1):270. (PMID: 31221203) J Clin Oncol. 2023 Feb 10;41(5):1105-1115. (PMID: 36288547) Lung Cancer. 2019 Aug;134:42-45. (PMID: 31319993) Cancer Res. 2003 Oct 1;63(19):6272-81. (PMID: 14559814) Oncogene. 2010 Apr 22;29(16):2346-56. (PMID: 20118985) JAMA Netw Open. 2023 Jul 3;6(7):e2323336. (PMID: 37459099) Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20. (PMID: 23315928) Clin Cancer Res. 2020 Jun 1;26(11):2615-2625. (PMID: 32034073) Arch Pathol Lab Med. 2017 Jun;141(6):751-758. (PMID: 28557599) Nat Commun. 2022 Jul 23;13(1):4264. (PMID: 35871175) Nat Biotechnol. 2013 Nov;31(11):1023-31. (PMID: 24142049) JTO Clin Res Rep. 2022 Jul 22;3(9):100381. (PMID: 36082279) Eur Arch Otorhinolaryngol. 2014 Feb;271(2):211-23. (PMID: 23467835) Int J Cancer. 2023 Mar 15;152(6):1259-1268. (PMID: 36408924) PLoS One. 2020 Sep 25;15(9):e0237802. (PMID: 32976510) Clin Cancer Res. 2018 Jul 1;24(13):3087-3096. (PMID: 29615460) J Chem Theory Comput. 2015 Aug 11;11(8):3584-3595. (PMID: 26300708) PLoS One. 2022 Mar 16;17(3):e0264138. (PMID: 35294956) JCO Precis Oncol. 2017 Jul;2017:. (PMID: 28890946) Cancer Discov. 2020 Jul;10(7):922-934. (PMID: 32532746) Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28201-28211. (PMID: 33106425) Nat Med. 2022 Aug;28(8):1640-1645. (PMID: 35962206) Eur J Cancer. 2012 Jun;48(9):1299-311. (PMID: 22464348) N Engl J Med. 2020 Sep 3;383(10):931-943. (PMID: 32469185) Mol Oncol. 2018 May;12(5):705-723. (PMID: 29570930) Nature. 2009 Dec 24;462(7276):1070-4. (PMID: 20033049) J Thorac Oncol. 2023 Apr;18(4):419-435. (PMID: 36441095) NPJ Precis Oncol. 2022 Dec 9;6(1):91. (PMID: 36494601) Nucleic Acids Res. 2012 Jul;40(Web Server issue):W452-7. (PMID: 22689647) Ann Oncol. 2023 Apr;34(4):339-357. (PMID: 36872130) JCO Precis Oncol. 2021 Aug 25;5:. (PMID: 34476332) Ann Oncol. 2019 Feb 1;30(2):325-331. (PMID: 30624546) J Chem Theory Comput. 2012 Sep 11;8(9):3314-21. (PMID: 26605738) J Thorac Oncol. 2021 Jun;16(6):1017-1029. (PMID: 33676017) J Thorac Oncol. 2019 Apr;14(4):606-616. (PMID: 30605727) Ann Transl Med. 2017 May;5(10):205. (PMID: 28603720) J Thorac Oncol. 2019 Oct;14(10):1753-1765. (PMID: 31279006) Cancer Res. 2021 May 1;81(9):2566-2573. (PMID: 33653773) J Chem Theory Comput. 2020 Sep 8;16(9):5526-5547. (PMID: 32692556) J Clin Oncol. 2023 Aug 20;41(24):e63-e72. (PMID: 37433095) J Mol Diagn. 2018 Sep;20(5):686-702. (PMID: 29936259) JCO Precis Oncol. 2022 Oct;6:e2200261. (PMID: 36265119) JAMA Oncol. 2022 Aug 1;8(8):1160-1168. (PMID: 35708671) J Mol Diagn. 2015 May;17(3):251-64. (PMID: 25801821) |
معلومات مُعتمدة: | R01 CA222823 United States CA NCI NIH HHS; T32 CA009207 United States CA NCI NIH HHS; T32-CA009207 American Society of Clinical Oncology (ASCO); AAPMRC2.2020.LCC/SB Ligue Contre le Cancer (French League Against Cancer) |
المشرفين على المادة: | EC 2.7.10.1 (Proto-Oncogene Proteins c-met) 0 (Protein Kinase Inhibitors) EC 2.7.10.1 (MET protein, human) |
تواريخ الأحداث: | Date Created: 20240402 Date Completed: 20240802 Latest Revision: 20240804 |
رمز التحديث: | 20240804 |
مُعرف محوري في PubMed: | PMC11294820 |
DOI: | 10.1158/2159-8290.CD-23-1217 |
PMID: | 38564707 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2159-8290 |
---|---|
DOI: | 10.1158/2159-8290.CD-23-1217 |