دورية أكاديمية
Self-Assembled STING-Activating Coordination Nanoparticles for Cancer Immunotherapy and Vaccine Applications.
| العنوان: | Self-Assembled STING-Activating Coordination Nanoparticles for Cancer Immunotherapy and Vaccine Applications. |
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| المؤلفون: | Sun X; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Huang X; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Park KS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Zhou X; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Kennedy AA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Pretto CD; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Wu Q; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Wan Z; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Xu Y; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Gong W; Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Cancer Biology at the University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, United States., Sexton JZ; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Tai AW; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Lei YL; Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Otolaryngology─Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Head and Neck Surgery, Department of Cancer Biology, Department of Translational Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, United States., Moon JJ; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States. |
| المصدر: | ACS nano [ACS Nano] 2024 Apr 16; Vol. 18 (15), pp. 10439-10453. Date of Electronic Publication: 2024 Apr 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Neoplasms*/therapy , Vaccines* , Nanoparticles*/chemistry, Animals ; Mice ; Adjuvants, Immunologic ; Immunotherapy/methods |
| مستخلص: | The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, and STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use in cancer immunotherapy and vaccines. However, the limited drug-like properties of CDN necessitate an efficient delivery system to the immune system. To address these challenges, we developed an immunostimulatory delivery system for STING agonists. Here, we have examined aqueous coordination interactions between CDN and metal ions and report that CDN mixed with Zn 2+ and Mn 2+ formed distinctive crystal structures. Further pharmaceutical engineering led to the development of a functional coordination nanoparticle, termed the Zinc-Mn-CDN Particle (ZMCP), produced by a simple aqueous one-pot synthesis. Local or systemic administration of ZMCP exerted robust antitumor efficacy in mice. Importantly, recombinant protein antigens from SARS-CoV-2 can be simply loaded during the aqueous one-pot synthesis. The resulting ZMCP antigens elicited strong cellular and humoral immune responses that neutralized SARS-CoV-2, highlighting ZMCP as a self-adjuvant vaccine platform against COVID-19 and other infectious pathogens. Overall, this work establishes a paradigm for developing translational coordination nanomedicine based on drug-metal ion coordination and broadens the applicability of coordination medicine for the delivery of proteins and other biologics. |
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| معلومات مُعتمدة: | R01 NS122536 United States NS NINDS NIH HHS; P30 CA046592 United States CA NCI NIH HHS; R44 CA281497 United States CA NCI NIH HHS; R01 DE031951 United States DE NIDCR NIH HHS; R01 CA271799 United States CA NCI NIH HHS; R01 DE030691 United States DE NIDCR NIH HHS; R01 DE026728 United States DE NIDCR NIH HHS; R01 GM139823 United States GM NIGMS NIH HHS; R01 DK125087 United States DK NIDDK NIH HHS; HHSN272201300006C United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: STING; cancer immunotherapy; coordination nanoparticle; cyclic dinucleotide; vaccine |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) 0 (Vaccines) |
| تواريخ الأحداث: | Date Created: 20240403 Date Completed: 20240417 Latest Revision: 20240617 |
| رمز التحديث: | 20240617 |
| مُعرف محوري في PubMed: | PMC11031738 |
| DOI: | 10.1021/acsnano.3c11374 |
| PMID: | 38567994 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1936-086X |
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| DOI: | 10.1021/acsnano.3c11374 |