دورية أكاديمية
أعرض في EDS

Ligand bias underlies differential signaling of multiple FGFs via FGFR1.

التفاصيل البيبلوغرافية
العنوان: Ligand bias underlies differential signaling of multiple FGFs via FGFR1.
المؤلفون: Karl K; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Del Piccolo N; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Light T; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Roy T; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Dudeja P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Fafilek B; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Hristova K; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States.
المصدر: ELife [Elife] 2024 Apr 03; Vol. 12. Date of Electronic Publication: 2024 Apr 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Signal Transduction* , Fibroblast Growth Factors*, Female ; Pregnancy ; Humans ; Ligands ; Phosphorylation ; Bias ; Receptor, Fibroblast Growth Factor, Type 1/genetics
مستخلص: The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences in FGFR1c signaling in response to FGF4, FGF8, and FGF9, a process which is relevant for limb bud outgrowth. We find that FGF8 preferentially induces FRS2 phosphorylation and extracellular matrix loss, while FGF4 and FGF9 preferentially induce FGFR1c phosphorylation and cell growth arrest. Thus, we demonstrate that FGF8 is a biased FGFR1c ligand, as compared to FGF4 and FGF9. Förster resonance energy transfer experiments reveal a correlation between biased signaling and the conformation of the FGFR1c transmembrane domain dimer. Our findings expand the mechanistic understanding of FGF signaling during development and bring the poorly understood concept of receptor tyrosine kinase ligand bias into the spotlight.
Competing Interests: KK, ND, TL, TR, PD, VU, BF, PK, KH No competing interests declared
(© 2023, Karl et al.)
References: Elife. 2017 Feb 15;6:. (PMID: 28199182)
Eur J Cell Biol. 1995 Jan;66(1):47-59. (PMID: 7750519)
Mol Cell Biol. 2013 Aug;33(15):2865-78. (PMID: 23716589)
Cytokine Growth Factor Rev. 2005 Apr;16(2):187-203. (PMID: 15863034)
Cancer Res. 2009 Jun 1;69(11):4613-20. (PMID: 19458078)
Elife. 2016 Apr 07;5:e13876. (PMID: 27052508)
J Biol Chem. 2006 Jun 9;281(23):15694-700. (PMID: 16597617)
Genome Biol. 2001;2(3):REVIEWS3005. (PMID: 11276432)
Osteoarthritis Cartilage. 2017 Sep;25(9):1522-1530. (PMID: 28583899)
Integr Biol (Camb). 2016 Feb;8(2):216-29. (PMID: 26787445)
Nat Struct Mol Biol. 2010 Apr;17(4):398-402. (PMID: 20228801)
Sci Signal. 2009 Feb 17;2(58):ra6. (PMID: 19224897)
Cell Adh Migr. 2014;8(4):360-5. (PMID: 25530219)
J Biol Chem. 1994 Jun 24;269(25):17056-61. (PMID: 7516330)
Nat Rev Mol Cell Biol. 2013 Mar;14(3):166-80. (PMID: 23403721)
Mol Cell Biol. 2010 Nov;30(22):5432-43. (PMID: 20837704)
Front Neurosci. 2017 Jan 24;11:17. (PMID: 28174517)
Genes Dev. 2007 Jun 15;21(12):1433-42. (PMID: 17575045)
Anal Chem. 2012 Oct 16;84(20):8650-5. (PMID: 22985263)
Mol Cell Biol. 2000 Feb;20(3):979-89. (PMID: 10629055)
Sci Signal. 2018 Sep 18;11(548):. (PMID: 30228226)
Curr Protoc Pharmacol. 2016 Sep 16;74:2.15.1-2.15.15. (PMID: 27636109)
J Pharmacol Exp Ther. 2015 Apr;353(1):132-49. (PMID: 25650377)
Mol Endocrinol. 2014 Mar;28(3):281-94. (PMID: 24433041)
Nat Struct Mol Biol. 2013 Aug;20(8):958-64. (PMID: 23812375)
J Cell Biol. 2003 Jun 23;161(6):1053-66. (PMID: 12821644)
J Biol Chem. 2019 May 31;294(22):8791-8805. (PMID: 31015204)
Nat Chem Biol. 2011 Aug 21;7(10):692-700. (PMID: 21857662)
J R Soc Interface. 2013 Oct 09;10(89):20130742. (PMID: 24108693)
J Cell Physiol. 2006 Jun;207(3):800-8. (PMID: 16523491)
Science. 2012 Mar 2;335(6072):1106-10. (PMID: 22267580)
Mol Cell. 2002 Oct;10(4):709-19. (PMID: 12419216)
Cell. 2010 Jun 25;141(7):1117-34. (PMID: 20602996)
Signal Transduct Target Ther. 2020 Sep 2;5(1):181. (PMID: 32879300)
Curr Cancer Drug Targets. 2009 May;9(3):419-38. (PMID: 19442060)
Annu Rev Biophys. 2017 May 22;46:175-198. (PMID: 28532213)
Chem Rev. 2019 May 8;119(9):5881-5921. (PMID: 30589534)
Bioessays. 2012 May;34(5):377-85. (PMID: 22415853)
J Thorac Oncol. 2021 Feb;16(2):205-215. (PMID: 33096270)
Pharmacol Rev. 2019 Apr;71(2):267-315. (PMID: 30914442)
Chem Biol. 2015 Jun 18;22(6):776-84. (PMID: 26091170)
PLoS One. 2013 Dec 04;8(12):e81569. (PMID: 24324705)
J Pharmacol Exp Ther. 2011 Feb;336(2):296-302. (PMID: 21030484)
Cell. 2000 Oct 13;103(2):211-25. (PMID: 11057895)
Biochemistry. 2006 May 23;45(20):6241-51. (PMID: 16700535)
Cell. 2011 Feb 4;144(3):402-13. (PMID: 21295700)
Eur Spine J. 2016 Jun;25(6):1821-9. (PMID: 26769035)
Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6503-6508. (PMID: 33351993)
Mol Cell. 2006 Mar 3;21(5):711-7. (PMID: 16507368)
Nat Rev Drug Discov. 2018 Apr;17(4):243-260. (PMID: 29302067)
Mol Pharmacol. 2011 Sep;80(3):367-77. (PMID: 21610196)
Am J Hum Genet. 2005 Feb;76(2):361-7. (PMID: 15625620)
Cytokine Growth Factor Rev. 2005 Apr;16(2):107-37. (PMID: 15863029)
Cell. 2017 Oct 19;171(3):683-695.e18. (PMID: 28988771)
J Am Chem Soc. 2010 Mar 17;132(10):3628-35. (PMID: 20158179)
Nat Commun. 2016 Oct 31;7:13307. (PMID: 27796308)
Biochem Biophys Res Commun. 2017 Jan 29;483(1):82-87. (PMID: 28057484)
J Biol Chem. 2020 Dec 25;295(52):18494-18507. (PMID: 33122191)
Curr Opin Struct Biol. 2021 Dec;71:193-199. (PMID: 34399300)
Science. 2013 May 3;340(6132):615-9. (PMID: 23519215)
Immunity. 2017 Jun 20;46(6):1005-1017.e5. (PMID: 28636951)
Biophys J. 2000 Jun;78(6):3036-47. (PMID: 10827982)
J Med Chem. 2014 Aug 28;57(16):6887-96. (PMID: 24697360)
Biophys J. 2021 Jan 5;120(1):55-63. (PMID: 33285113)
Nat Commun. 2016 Jan 04;7:10262. (PMID: 26725515)
J Biol Chem. 2004 Jan 16;279(3):1747-56. (PMID: 14593093)
Sci Signal. 2010 Nov 30;3(150):ra86. (PMID: 21119106)
Oncogene. 2008 Dec 11;27(58):7260-73. (PMID: 18794797)
Nature. 2008 May 15;453(7193):401-5. (PMID: 18449196)
Elife. 2016 Mar 28;5:. (PMID: 27017828)
J Cell Sci. 2002 Feb 1;115(Pt 3):553-62. (PMID: 11861762)
Bone. 2010 Jul;47(1):102-10. (PMID: 20362703)
J Biol Chem. 1996 Jun 21;271(25):15292-7. (PMID: 8663044)
Prog Mol Biol Transl Sci. 2018;160:63-104. (PMID: 30470293)
Commun Biol. 2018 Feb 22;1:15. (PMID: 30271902)
Cancer Sci. 2008 Jul;99(7):1319-25. (PMID: 18452557)
Science. 2004 Nov 26;306(5701):1506-7. (PMID: 15567848)
Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):561-576. (PMID: 27884807)
Nat Rev Drug Discov. 2013 Jun;12(6):483. (PMID: 23681003)
Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49. (PMID: 15863030)
Acc Chem Res. 2015 Aug 18;48(8):2262-9. (PMID: 26244699)
Mol Cell Biol. 1998 Jul;18(7):3966-73. (PMID: 9632781)
Virchows Arch. 2014 Nov;465(5):547-58. (PMID: 25086725)
Sci Signal. 2020 Aug 18;13(645):. (PMID: 32817373)
Cancer Res. 2010 Mar 1;70(5):2085-94. (PMID: 20179196)
Am J Med Genet. 1998 Jul 7;78(3):237-41. (PMID: 9677057)
Nat Methods. 2019 Jun;16(6):493-496. (PMID: 31110281)
J Cell Physiol. 1987 Apr;131(1):123-30. (PMID: 3032990)
Mol Endocrinol. 2007 Apr;21(4):987-1000. (PMID: 17284663)
Adv Cancer Res. 2020;147:109-160. (PMID: 32593399)
J Biol Chem. 1994 Feb 11;269(6):3976-84. (PMID: 8307953)
Nature. 2003 May 15;423(6937):319-25. (PMID: 12748649)
J Biol Chem. 2020 Jul 17;295(29):9917-9933. (PMID: 32467228)
Sci Transl Med. 2021 May 5;13(592):. (PMID: 33952673)
Cell Mol Life Sci. 2015 Jun;72(12):2445-59. (PMID: 25854632)
ACS Chem Biol. 2012 Aug 17;7(8):1367-76. (PMID: 22667988)
Trends Genet. 2000 Jun;16(6):265-71. (PMID: 10827454)
J Biol Chem. 2002 Feb 8;277(6):4018-23. (PMID: 11729184)
معلومات مُعتمدة: R01 GM068619 United States GM NIGMS NIH HHS; GM068619 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: FGFR; biased signaling; molecular biophysics; none; signal transduction; structural biology
المشرفين على المادة: 0 (Ligands)
62031-54-3 (Fibroblast Growth Factors)
EC 2.7.10.1 (FGFR1 protein, human)
EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240404 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC10990489
DOI: 10.7554/eLife.88144
PMID: 38568193
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.88144