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Metals/bisulfite system involved generation of 24-sulfonic-25-ene ginsenoside Rg1, a potential quality control marker for sulfur-fumigated ginseng.

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العنوان: Metals/bisulfite system involved generation of 24-sulfonic-25-ene ginsenoside Rg1, a potential quality control marker for sulfur-fumigated ginseng.
المؤلفون: Liu H; Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Department of Pharmacy, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China., Wu XQ; Department of Oncology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China., Qin XL; Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China., Zhu JH; Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China., Xu JD; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China., Zhou SS; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China., Kong M; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China., Shen H; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China., Huo JG; Department of Oncology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. Electronic address: huojiege@jsatcm.com., Li SL; Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China. Electronic address: songlinli64@126.com., Zhu H; Drug Clinical Trial Center, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou 225300, China; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, China. Electronic address: zhuhev@163.com.
المصدر: Food chemistry [Food Chem] 2024 Aug 01; Vol. 448, pp. 139112. Date of Electronic Publication: 2024 Mar 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
مواضيع طبية MeSH: Ginsenosides*/chemistry , Ginsenosides*/analysis , Panax*/chemistry , Fumigation* , Sulfur*/chemistry , Quality Control*, Sulfites/chemistry ; Sulfites/analysis ; Metals/chemistry ; Metals/analysis ; Plant Extracts/chemistry
مستخلص: Ginseng is a most popular health-promoting food with ginsenosides as its main bioactive ingredients. Illegal sulfur-fumigation causes ginsenosides convert to toxic sulfur-containing derivatives, and reduced the efficacy/safety of ginseng. 24-sulfo-25-ene ginsenoside Rg1 (25-ene SRg1), one of the sulfur-containing derivatives, is a potential quality control marker of fumigated ginseng, but with low accessibility owing to its unknown generation mechanism. In this study, metals/bisulfite system involved generation mechanism was investigated and verified. The generation of 25-ene SRg1 in sulfur-fumigated ginseng is that SO 2 , formed during sulfur-fumigation, reacted with water and ionized into HSO 3 - . On the one hand, under the metals/bisulfite system, HSO 3 - generates HSO 5 - and free radicals which converted ginsenoside Rg1 to 24,25-epoxide Rg1; on the other hand, as a nucleophilic group, HSO 3 - reacted with 24,25-epoxide Rg1 and further dehydrated to 25-ene SRg1. This study provided a technical support for the promotion of 25-ene SRg1 as the characteristic quality control marker of sulfur-fumigated ginseng.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: 24-sulfo-25-ene ginsenoside Rg1; 24-sulfo-25-hydroxy ginsenoside Rg1; Generation mechanism; Ginseng; Metals/bisulfite system; Sulfur-fumigation
المشرفين على المادة: 0 (Ginsenosides)
PJ788634QY (ginsenoside Rg1)
70FD1KFU70 (Sulfur)
0 (Sulfites)
0 (Metals)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240424 Latest Revision: 20240424
رمز التحديث: 20240425
DOI: 10.1016/j.foodchem.2024.139112
PMID: 38569404
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7072
DOI:10.1016/j.foodchem.2024.139112