دورية أكاديمية
أعرض في EDS

Acute quadruple extremity compartment syndrome due to angio-oedema after polypharmacy overdose including olmesartan medoxomil, telmisartan and vildagliptin.

التفاصيل البيبلوغرافية
العنوان: Acute quadruple extremity compartment syndrome due to angio-oedema after polypharmacy overdose including olmesartan medoxomil, telmisartan and vildagliptin.
المؤلفون: Kono Y; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan., Takimoto K; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan mm7706tk@gmail.com., Fujii M; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan., Hayashi Y; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
المصدر: BMJ case reports [BMJ Case Rep] 2024 Apr 02; Vol. 17 (4). Date of Electronic Publication: 2024 Apr 02.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Pub. Group
مواضيع طبية MeSH: Drug Overdose*/drug therapy , Angioedema*/drug therapy , Hypertension*/drug therapy, Middle Aged ; Female ; Humans ; Olmesartan Medoxomil/therapeutic use ; Telmisartan/adverse effects ; Vildagliptin/adverse effects ; Polypharmacy ; Amlodipine/adverse effects ; Tetrazoles/adverse effects ; Antihypertensive Agents/adverse effects
مستخلص: This case report describes a rare manifestation of acute compartment syndrome (ACS) involving all four extremities, precipitated by angio-oedema in a middle-aged woman who consumed an overdose of multiple medications: nifedipine, azelnidipine, amlodipine besylate, olmesartan medoxomil, telmisartan, esaxerenone and vildagliptin. She presented with haemodynamic instability, necessitating intubation. Despite stabilising haemodynamic parameters within 24 hours, she manifested escalating extremity oedema. At 52 hours after ingestion, mottled skin was observed, along with necrotic alterations in the swollen hands and compartment pressures exceeding 30 mm Hg in all extremities. ACS was diagnosed, leading to fasciotomies. The aetiology is postulated to be drug-induced angio-oedema, possibly intensified by the concurrent overdose of olmesartan medoxomil, telmisartan and vildagliptin, each of which has a risk of angio-oedema even at standard dosages. This scenario is a very rare case caused by drug-induced angio-oedema, which underscores the importance of vigilant monitoring to detect ACS in patients with progressing limb oedema.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: Adult intensive care; Drug interactions; Drugs misuse (including addiction); Orthopaedic and trauma surgery
المشرفين على المادة: 6M97XTV3HD (Olmesartan Medoxomil)
U5SYW473RQ (Telmisartan)
I6B4B2U96P (Vildagliptin)
1J444QC288 (Amlodipine)
0 (Tetrazoles)
0 (Antihypertensive Agents)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240405 Latest Revision: 20240521
رمز التحديث: 20240521
مُعرف محوري في PubMed: PMC10989128
DOI: 10.1136/bcr-2023-259485
PMID: 38569737
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-790X
DOI:10.1136/bcr-2023-259485