دورية أكاديمية
أعرض في EDS

Intrinsic disorder in the human vitreous proteome.

التفاصيل البيبلوغرافية
العنوان: Intrinsic disorder in the human vitreous proteome.
المؤلفون: Antonietti M; Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America., Taylor Gonzalez DJ; Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America., Djulbegovic MB; Wills Eye Hospital, Thomas Jefferson University Hospital, Philadelphia, PA, United States of America., Gameiro GR; Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America; Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, SP, Brazil., Uversky VN; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States of America., Sridhar J; Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America., Karp CL; Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America. Electronic address: ckarp@med.miami.edu.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 267 (Pt 1), pp. 131274. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
مواضيع طبية MeSH: Intrinsically Disordered Proteins*/metabolism , Intrinsically Disordered Proteins*/chemistry , Proteome*/metabolism , Vitreous Body*/metabolism, Humans ; Eye Proteins/metabolism
مستخلص: The vitreous is a vital component of the eye, occupying a substantial portion of its volume and maintaining its structure. This study delves into the presence and significance of intrinsically disordered proteins (IDPs) within the vitreous, utilizing a dataset of 1240 vitreous proteins previously discovered in the vitreous proteome by Murthy et al.in five healthy subjects. The results indicate that 26.9 % of vitreous proteins are highly disordered, 68.8 % possess moderate disorder, and only 4.3 % are highly ordered. A complex interaction network among these proteins suggests their biological importance, and approximately 25 % may undergo liquid-liquid phase separation (LLPS). These findings offer new perspectives on the vitreous' molecular composition and behavior, potentially impacting our understanding of eye-related diseases, physiological changes such as vitreous syneresis. Further research is needed to translate these insights into clinical applications, although the intrinsic protein disorder and its association with LLPS appears to play a role in vitreous proteome function.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: P30 EY014801 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: Intrinsically disordered proteins (IDPs); Proteomics; Vitreous humor
المشرفين على المادة: 0 (Intrinsically Disordered Proteins)
0 (Proteome)
0 (Eye Proteins)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240507 Latest Revision: 20240619
رمز التحديث: 20240619
مُعرف محوري في PubMed: PMC11182622
DOI: 10.1016/j.ijbiomac.2024.131274
PMID: 38569991
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0003
DOI:10.1016/j.ijbiomac.2024.131274