دورية أكاديمية
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Characterisation of behaviours relevant to apathy syndrome in the aged male rat.

التفاصيل البيبلوغرافية
العنوان: Characterisation of behaviours relevant to apathy syndrome in the aged male rat.
المؤلفون: Jackson MG; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK. Electronic address: megan.jackson@bristol.ac.uk., Lightman SL; Bristol Medical School: Translational Health Sciences, University of Bristol, Bristol, UK., Robinson ESJ; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
المصدر: Behavioural brain research [Behav Brain Res] 2024 May 28; Vol. 466, pp. 114977. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Apathy*/physiology , Aging*/physiology , Reward* , Motivation*/physiology , Anxiety*/physiopathology , Disease Models, Animal*, Animals ; Male ; Rats ; Behavior, Animal/physiology ; Reversal Learning/physiology ; Exploratory Behavior/physiology
مستخلص: Apathy is a complex psychiatric syndrome characterised by motivational deficit, emotional blunting and cognitive changes. It occurs alongside a broad range of neurological disorders, but also occurs in otherwise healthy ageing. Despite its clinical prevalence, apathy does not yet have a designated treatment strategy. Generation of a translational animal model of apathy syndrome would facilitate the development of novel treatments. Given the multidimensional nature of apathy, a model cannot be achieved with a single behavioural test. Using a battery of behavioural tests we investigated whether aged rats exhibit behavioural deficits across different domains relevant to apathy. Using the effort for reward and progressive ratio tasks we found that aged male rats (21-27 months) show intact reward motivation. Using the novelty supressed feeding test and position-based object exploration we found aged rats showed increased anxiety-like behaviour inconsistent with emotional blunting. The sucrose preference test and reward learning assay showed intact reward sensitivity and reward-related cognition in aged rats. However, using a bowl-digging version of the probabilistic reversal learning task, we found a deficit in cognitive flexibility in aged rats that did not translate across to a touchscreen version of the task. While these data reveal important changes in cognitive flexibility and anxiety associated with ageing, aged rats do not show deficits across other behavioural domains relevant to apathy. This suggests that aged rats are not a suitable model for age-related apathy syndrome. These findings contrast with previous work in mice, revealing important species differences in behaviours relevant to apathy syndrome in ageing.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare in relation to the studies reported in this manuscript. ESJR has currently or previously received funding for academic collaborations or contract research from Boehringer Ingelheim, COMPASS Pathways, Eli Lilly, IRlab Therapeutics, Pfizer, MSD, and SmallPharma but these have no direct relationship to the work presented here.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Apathy; ageing; animal model; behaviour; rat
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240427 Latest Revision: 20240427
رمز التحديث: 20240428
DOI: 10.1016/j.bbr.2024.114977
PMID: 38570074
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7549
DOI:10.1016/j.bbr.2024.114977