دورية أكاديمية
أعرض في EDS

Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.

التفاصيل البيبلوغرافية
العنوان: Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.
المؤلفون: Leduc T; Department of Neuroscience, Université de Montréal, Montreal, QC, Canada.; Centre d'études avancées en médecine du sommeil (CÉAMS), Recherche - Centre intégré universitaire de santé et services sociaux du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada.; Centre de recherche du Centre hospitalier de l'Université de Montréal, 900, St-Denis street, Tour Viger Montréal, Montreal, QC, H2X 0A9, Canada., El Alami H; Department of Neuroscience, Université de Montréal, Montreal, QC, Canada.; Centre d'études avancées en médecine du sommeil (CÉAMS), Recherche - Centre intégré universitaire de santé et services sociaux du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada., Bougadir K; Department of Neuroscience, Université de Montréal, Montreal, QC, Canada.; Centre d'études avancées en médecine du sommeil (CÉAMS), Recherche - Centre intégré universitaire de santé et services sociaux du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada., Bélanger-Nelson E; Centre d'études avancées en médecine du sommeil (CÉAMS), Recherche - Centre intégré universitaire de santé et services sociaux du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada.; Pfizer Canada ULC, Montreal, QC, Canada., Mongrain V; Department of Neuroscience, Université de Montréal, Montreal, QC, Canada. valerie.mongrain@umontreal.ca.; Centre d'études avancées en médecine du sommeil (CÉAMS), Recherche - Centre intégré universitaire de santé et services sociaux du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada. valerie.mongrain@umontreal.ca.; Centre de recherche du Centre hospitalier de l'Université de Montréal, 900, St-Denis street, Tour Viger Montréal, Montreal, QC, H2X 0A9, Canada. valerie.mongrain@umontreal.ca.
المصدر: Molecular autism [Mol Autism] 2024 Apr 03; Vol. 15 (1), pp. 13. Date of Electronic Publication: 2024 Apr 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101534222 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-2392 (Electronic) NLM ISO Abbreviation: Mol Autism Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central
مواضيع طبية MeSH: Sleep Deprivation*/metabolism , Sleep, Slow-Wave*, Animals ; Humans ; Mice ; Electroencephalography ; Neuroligins ; Quality of Life ; Sleep/physiology
مستخلص: Background: Sleep disturbances are a common comorbidity to most neurodevelopmental disorders and tend to worsen disease symptomatology. It is thus crucial to understand mechanisms underlying sleep disturbances to improve patients' quality of life. Neuroligin-2 (NLGN2) is a synaptic adhesion protein regulating GABAergic transmission. It has been linked to autism spectrum disorders and schizophrenia in humans, and deregulations of its expression were shown to cause epileptic-like hypersynchronized cerebral activity in rodents. Importantly, the absence of Nlgn2 (knockout: KO) was previously shown to alter sleep-wake duration and quality in mice, notably increasing slow-wave sleep (SWS) delta activity (1-4 Hz) and altering its 24-h dynamics. This type of brain oscillation is involved in memory consolidation, and is also a marker of homeostatic sleep pressure. Sleep deprivation (SD) is notably known to impair cognition and the physiological response to sleep loss involves GABAergic transmission.
Methods: Using electrocorticographic (ECoG) recordings, we here first aimed to verify how individual slow wave (SW; 0.5-4 Hz) density and properties (e.g., amplitude, slope, frequency) contribute to the higher SWS delta activity and altered 24-h dynamics observed in Nlgn2 KO mice. We further investigated the response of these animals to SD. Finally, we tested whether sleep loss affects the gene expression of Nlgn2 and related GABAergic transcripts in the cerebral cortex of wild-type mice using RNA sequencing.
Results: Our results show that Nlgn2 KO mice have both greater SW amplitude and density, and that SW density is the main property contributing to the altered 24-h dynamics. We also found the absence of Nlgn2 to accelerate paradoxical sleep recovery following SD, together with profound alterations in ECoG activity across vigilance states. Sleep loss, however, did not modify the 24-h distribution of the hypersynchronized ECoG events observed in these mice. Finally, RNA sequencing confirmed an overall decrease in cortical expression of Nlgn2 and related GABAergic transcripts following SD in wild-type mice.
Conclusions: This work brings further insight into potential mechanisms of sleep duration and quality deregulation in neurodevelopmental disorders, notably involving NLGN2 and GABAergic neurotransmission.
(© 2024. The Author(s).)
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معلومات مُعتمدة: PJT-178117 Canada CIHR
فهرسة مساهمة: Keywords: Cerebral cortex; GABAergic neurotransmission; Gene expression; Mice; Sleep deprivation; Sleep-wake regulation; Slow waves; Synaptic adhesion molecules
المشرفين على المادة: 0 (Neuroligins)
0 (neuroligin 2)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240405 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC10993465
DOI: 10.1186/s13229-024-00594-5
PMID: 38570872
قاعدة البيانات: MEDLINE
الوصف
تدمد:2040-2392
DOI:10.1186/s13229-024-00594-5