دورية أكاديمية
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Exploring volumetric abnormalities in subcortical L-HPA axis structures in pediatric generalized anxiety disorder.

التفاصيل البيبلوغرافية
العنوان: Exploring volumetric abnormalities in subcortical L-HPA axis structures in pediatric generalized anxiety disorder.
المؤلفون: Ysbæk-Nielsen AT; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
المصدر: Nordic journal of psychiatry [Nord J Psychiatry] 2024 Jul; Vol. 78 (5), pp. 402-410. Date of Electronic Publication: 2024 Apr 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100927567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-4725 (Electronic) Linking ISSN: 08039488 NLM ISO Abbreviation: Nord J Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: Oslo ; Boston : Scandinavian University Press, c1999-
مواضيع طبية MeSH: Magnetic Resonance Imaging* , Anxiety Disorders*/diagnostic imaging , Anxiety Disorders*/pathology , Anxiety Disorders*/physiopathology , Amygdala*/pathology , Amygdala*/diagnostic imaging , Amygdala*/physiopathology , Hippocampus*/pathology , Hippocampus*/diagnostic imaging , Thalamus*/diagnostic imaging , Thalamus*/pathology , Thalamus*/physiopathology , Hypothalamo-Hypophyseal System*/physiopathology , Hypothalamo-Hypophyseal System*/pathology , Hypothalamo-Hypophyseal System*/metabolism, Humans ; Male ; Female ; Child ; Child, Preschool ; Pituitary-Adrenal System/physiopathology ; Pituitary-Adrenal System/pathology
مستخلص: Background: Pediatric generalized anxiety disorder (GAD) is debilitating and increasingly prevalent, yet its etiology remains unclear. Some believe the disorder to be propagated by chronic dysregulation of the limbic-hypothalamic-pituitary-adrenal (L-HPA) axis, but morphometric studies of implicated subcortical areas have been largely inconclusive. Recognizing that certain subcortical subdivisions are more directly involved in L-HPA axis functioning, this study aims to detect specific abnormalities in these critical areas.
Methods: Thirty-eight MRI scans of preschool children with ( n  = 15) and without ( n  = 23) GAD underwent segmentation and between-group volumetric comparisons of the basolateral amygdala (BLA), ventral hippocampal subiculum (vSC), and mediodorsal medial magnocellular (MDm) area of the thalamus.
Results: Children with GAD displayed significantly larger vSC compared to healthy peers, F (1, 31) = 6.50, p FDR  = .048. On average, children with GAD presented with larger BLA and MDm, F s(1, 31) ≥ 4.86, p s FDR  ≤ .054. Exploratory analyses revealed right-hemispheric lateralization of all measures, most notably the MDm, F (1, 31) = 8.13, p FDR  = .024, the size of which scaled with symptom severity, r  = .83, p FDR  = .033.
Conclusion: The BLA, vSC, and MDm are believed to be involved in the regulation of anxiety and stress, both individually and collectively through the excitation and inhibition of the L-HPA axis. All were found to be enlarged in children with GAD, perhaps reflecting hypertrophy related to hyperexcitability, or early neuronal overgrowth. Longitudinal studies should investigate the relationship between these early morphological differences and the long-term subcortical atrophy previously observed.
فهرسة مساهمة: Keywords: Neuroimaging; generalized anxiety disorder; hypothalamic-pituitary-adrenal axis; structural MRI
تواريخ الأحداث: Date Created: 20240404 Date Completed: 20240627 Latest Revision: 20240627
رمز التحديث: 20240627
DOI: 10.1080/08039488.2024.2335980
PMID: 38573199
قاعدة البيانات: MEDLINE
الوصف
تدمد:1502-4725
DOI:10.1080/08039488.2024.2335980