دورية أكاديمية
أعرض في EDS

Combined exposure to hypoxia and nanoplastics leads to negative synergistic oxidative stress-mediated effects in the water flea Daphnia magna.

التفاصيل البيبلوغرافية
العنوان: Combined exposure to hypoxia and nanoplastics leads to negative synergistic oxidative stress-mediated effects in the water flea Daphnia magna.
المؤلفون: Lee Y; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Kim DH; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Lee JS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea., Kim HS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea., Maszczyk P; Department of Hydrobiology, Faculty of Biology, University of Warsaw, Warsaw, Poland., Wang M; Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment & Ecology, Xiamen University, Xiamen 361102, China., Yang Z; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, China., Wang DZ; State Key Laboratory of Marine Environmental Science, College of the Environment & Ecology, Xiamen University, Xiamen 361102, China., Lee JS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address: jslee2@skku.edu.
المصدر: Marine pollution bulletin [Mar Pollut Bull] 2024 May; Vol. 202, pp. 116306. Date of Electronic Publication: 2024 Apr 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0260231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3363 (Electronic) Linking ISSN: 0025326X NLM ISO Abbreviation: Mar Pollut Bull Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : Oxford : Elsevier
Original Publication: London, Macmillan.
مواضيع طبية MeSH: Daphnia magna*/drug effects , Daphnia magna*/physiology , Oxidative Stress* , Water Pollutants, Chemical*/toxicity, Animals ; Hypoxia ; Reactive Oxygen Species/metabolism
مستخلص: In this study, we investigated the combined effects of hypoxia and NPs on the water flea Daphnia magna, a keystone species in freshwater environments. To measure and understand the oxidative stress responses, we used acute toxicity tests, fluorescence microscopy, enzymatic assays, Western blot analyses, and Ingenuity Pathway Analysis. Our findings demonstrate that hypoxia and NPs exhibit a negative synergy that increases oxidative stress, as indicated by heightened levels of reactive oxygen species and antioxidant enzyme activity. These effects lead to more severe reproductive and growth impairments in D. magna compared to a single-stressor exposure. In this work, molecular investigations revealed complex pathway activations involving HIF-1α, NF-κB, and mitogen-activated protein kinase, illustrating the intricate molecular dynamics that can occur in combined stress conditions. The results underscore the amplified physiological impacts of combined environmental stressors and highlight the need for integrated strategies in the management of aquatic ecosystems.
Competing Interests: Declaration of competing interest The authors declare no competing financial interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Antioxidant system; Daphnia magna; HIF-1α pathway; Hypoxia; Oxidative stress
المشرفين على المادة: 0 (Reactive Oxygen Species)
0 (Water Pollutants, Chemical)
تواريخ الأحداث: Date Created: 20240404 Date Completed: 20240507 Latest Revision: 20240614
رمز التحديث: 20240615
DOI: 10.1016/j.marpolbul.2024.116306
PMID: 38574500
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3363
DOI:10.1016/j.marpolbul.2024.116306