دورية أكاديمية
Evidence for grid-cell-like activity in the time domain.
| العنوان: | Evidence for grid-cell-like activity in the time domain. |
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| المؤلفون: | Peters-Founshtein G; The Computational Neuropsychiatry Lab, Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Department of Nuclear Medicine, Sheba Medical Center, Ramat-Gan, Israel. Electronic address: Gregory.PetersFounshtein@sheba.health.gov.il., Dafni-Merom A; The Computational Neuropsychiatry Lab, Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Monsa R; The Computational Neuropsychiatry Lab, Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Arzy S; The Computational Neuropsychiatry Lab, Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Department of Neurology, Hadassah Hebrew University Medical School, Jerusalem, Israel. |
| المصدر: | Neuropsychologia [Neuropsychologia] 2024 Jun 06; Vol. 198, pp. 108878. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0020713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3514 (Electronic) Linking ISSN: 00283932 NLM ISO Abbreviation: Neuropsychologia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford. |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging* , Grid Cells*/physiology , Brain Mapping*, Humans ; Male ; Female ; Adult ; Young Adult ; Time Perception/physiology ; Space Perception/physiology ; Entorhinal Cortex/physiology ; Entorhinal Cortex/diagnostic imaging ; Imagination/physiology ; Brain/physiology ; Brain/diagnostic imaging ; Image Processing, Computer-Assisted |
| مستخلص: | The relation between the processing of space and time in the brain has been an enduring cross-disciplinary question. Grid cells have been recognized as a hallmark of the mammalian navigation system, with recent studies attesting to their involvement in the organization of conceptual knowledge in humans. To determine whether grid-cell-like representations support temporal processing, we asked subjects to mentally simulate changes in age and time-of-day, each constituting "trajectory" in an age-day space, while undergoing fMRI. We found that grid-cell-like representations supported trajecting across this age-day space. Furthermore, brain regions concurrently coding past-to-future orientation positively modulated the magnitude of grid-cell-like representation in the left entorhinal cortex. Finally, our findings suggest that temporal processing may be supported by spatially modulated systems, and that innate regularities of abstract domains may interface and alter grid-cell-like representations, similarly to spatial geometry. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Cognitive maps; Entorhinal cortex; Grid-code; Navigation; fMRI |
| تواريخ الأحداث: | Date Created: 20240404 Date Completed: 20240501 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.neuropsychologia.2024.108878 |
| PMID: | 38574806 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3514 |
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| DOI: | 10.1016/j.neuropsychologia.2024.108878 |