دورية أكاديمية
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Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex.

التفاصيل البيبلوغرافية
العنوان: Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex.
المؤلفون: Moreira-Pais A; Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP) and Laboratory for Integrative and Translational Research in Population Health (ITR), 4200-450, Porto, Portugal; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal; Centre for Research and Technology of Agro Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801, Vila Real, Portugal. Electronic address: alexandrapais@ua.pt., Vitorino R; iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: rvitorino@ua.pt., Sousa-Mendes C; Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319, Porto, Portugal. Electronic address: csmendes@med.up.pt., Neuparth MJ; Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP) and Laboratory for Integrative and Translational Research in Population Health (ITR), 4200-450, Porto, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116, Gandra, Portugal. Electronic address: mneuparth@hotmail.com., Nuccio A; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128, Palermo, Italy. Electronic address: alessandro.nuccio@community.unipa.it., Luparello C; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128, Palermo, Italy. Electronic address: claudio.luparello@unipa.it., Attanzio A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128, Palermo, Italy. Electronic address: alessandro.attanzio@unipa.it., Novák P; Laboratory of Structural Biology and Cell Signalling, Institute of Microbiology of the Czech Academy of Sciences, Prumyslova 595, CZ-252 50, Vestec, Czech Republic. Electronic address: pnovak@biomed.cas.cz., Loginov D; Laboratory of Structural Biology and Cell Signalling, Institute of Microbiology of the Czech Academy of Sciences, Prumyslova 595, CZ-252 50, Vestec, Czech Republic. Electronic address: dmitry.loginov@biomed.cas.cz., Nogueira-Ferreira R; Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319, Porto, Portugal. Electronic address: rmferreira@med.up.pt., Leite-Moreira A; Cardiovascular R&D Center - UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319, Porto, Portugal; Department of Cardiothoracic Surgery, Centro Hospitalar Universitário São João, 4200-319, Porto, Portugal. Electronic address: amoreira@med.up.pt., Oliveira PA; Centre for Research and Technology of Agro Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801, Vila Real, Portugal. Electronic address: pamo@utad.pt., Ferreira R; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: ritaferreira@ua.pt., Duarte JA; UCIBIO - Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116, Gandra, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, University Institute of Health Sciences - CESPU, 4585-116, Gandra, Portugal. Electronic address: jose.duarte@iucs.cespu.pt.
المصدر: Free radical biology & medicine [Free Radic Biol Med] 2024 Jun; Vol. 218, pp. 68-81. Date of Electronic Publication: 2024 Apr 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown, NY : Elsevier Science
Original Publication: New York : Pergamon, c1987-
مواضيع طبية MeSH: Muscle, Skeletal*/metabolism , Muscle, Skeletal*/pathology , Aging*/metabolism , Sarcopenia*/metabolism , Sarcopenia*/pathology, Animals ; Male ; Female ; Rats ; Mitochondria, Muscle/metabolism ; Mitochondria, Muscle/pathology ; Estradiol/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Fibrosis/metabolism ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Proteome/metabolism ; Sex Factors ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitophagy
مستخلص: Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the proteome profiling of mitochondria-enriched fractions. To the best of our knowledge, this is the first study analyzing sex differences in skeletal muscle mitochondrial proteome remodeling. Data demonstrated that age induced skeletal muscle atrophy and fibrosis in both sexes. In females, however, this adverse skeletal muscle remodeling was more accentuated than in males and might be attributed to an age-related reduction of 17beta-estradiol signaling through its estrogen receptor alpha located in mitochondria. The females-specific mitochondrial remodeling encompassed increased abundance of proteins involved in fatty acid oxidation, decreased abundance of the complexes subunits, and enhanced proneness to oxidative posttranslational modifications. This conceivable accretion of damaged mitochondria in old females might be ascribed to low levels of Parkin, a key mediator of mitophagy. Despite skeletal muscle atrophy and fibrosis, males maintained their testosterone levels throughout aging, as well as their androgen receptor content, and the age-induced mitochondrial remodeling was limited to increased abundance of pyruvate dehydrogenase E1 component subunit beta and electron transfer flavoprotein subunit beta. Herein, for the first time, it was demonstrated that age affects more severely the skeletal muscle mitochondrial proteome of females, reinforcing the necessity of sex-personalized approaches towards sarcopenia management, and the inevitability of the assessment of mitochondrion-related therapeutics.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Fatty acid oxidation; Mitophagy; Oxidative phosphorylation; Sarcopenia; Sexual dimorphism
المشرفين على المادة: 4TI98Z838E (Estradiol)
EC 2.3.2.27 (Ubiquitin-Protein Ligases)
EC 2.3.2.27 (parkin protein)
0 (Proteome)
تواريخ الأحداث: Date Created: 20240404 Date Completed: 20240430 Latest Revision: 20240430
رمز التحديث: 20240501
DOI: 10.1016/j.freeradbiomed.2024.04.005
PMID: 38574975
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4596
DOI:10.1016/j.freeradbiomed.2024.04.005