دورية أكاديمية
Effects of dietary iron deficiency or overload on bone: Dietary details matter.
| العنوان: | Effects of dietary iron deficiency or overload on bone: Dietary details matter. |
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| المؤلفون: | Baschant U; Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany., Fuqua BK; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Ledesma-Colunga M; Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany., Vulpe CD; Department of Physiological Sciences, University of Florida Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA., McLachlan S; Usher Institute, The University of Edinburgh, Edinburgh, UK., Hofbauer LC; Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany., Lusis AJ; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Rauner M; Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany. Electronic address: martina.rauner@ukdd.de. |
| المصدر: | Bone [Bone] 2024 Jul; Vol. 184, pp. 117092. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Elmsford, NY : Pergamon Press, c1985- |
| مواضيع طبية MeSH: | Bone and Bones*/metabolism , Bone and Bones*/drug effects , Iron Overload*/metabolism, Animals ; Male ; Mice ; Iron Deficiencies ; Diet ; Mice, Inbred C57BL ; Iron, Dietary/administration & dosage ; Liver/metabolism |
| مستخلص: | Purpose: Bone is susceptible to fluctuations in iron homeostasis, as both iron deficiency and overload are linked to poor bone strength in humans. In mice, however, inconsistent results have been reported, likely due to different diet setups or genetic backgrounds. Here, we assessed the effect of different high and low iron diets on bone in six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H/HeJ, and DBA/2J). Methods: Mice received a high (20,000 ppm) or low-iron diet (∼10 ppm) after weaning for 6-8 weeks. For C57BL/6J males, we used two dietary setups with similar amounts of iron, yet different nutritional compositions that were either richer ("TUD study") or poorer ("UCLA study") in minerals and vitamins. After sacrifice, liver, blood and bone parameters as well as bone turnover markers in the serum were analyzed. Results: Almost all mice on the UCLA study high iron diet had a significant decrease of cortical and trabecular bone mass accompanied by high bone resorption. Iron deficiency did not change bone microarchitecture or turnover in C57BL/6J, A/J, and DBA/2J mice, but increased trabecular bone mass in BALB/cJ, C3H/HeJ and AKR/J mice. In contrast to the UCLA study, male C57BL/6J mice in the TUD study did not display any changes in trabecular bone mass or turnover on high or low iron diet. However, cortical bone parameters were also decreased in TUD mice on the high iron diet. Conclusion: Thus, these data show that cortical bone is more susceptible to iron overload than trabecular bone and highlight the importance of a nutrient-rich diet to potentially mitigate the negative effects of iron overload on bone. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bone; Mouse strains; iron deficiency; iron diet; iron overload |
| تواريخ الأحداث: | Date Created: 20240404 Date Completed: 20240518 Latest Revision: 20240518 |
| رمز التحديث: | 20240519 |
| DOI: | 10.1016/j.bone.2024.117092 |
| PMID: | 38575048 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-2763 |
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| DOI: | 10.1016/j.bone.2024.117092 |