دورية أكاديمية
Brazil nut consumption reduces DNA damage in overweight type 2 diabetes mellitus patients.
| العنوان: | Brazil nut consumption reduces DNA damage in overweight type 2 diabetes mellitus patients. |
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| المؤلفون: | Macan TP; Laboratory of Translational Biomedicine, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil; Environmental Health Department, Portuguese National Institute of Health Dr. Ricardo Jorge, Porto, Portugal., Magenis ML; Laboratory of Translational Biomedicine, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Damiani AP; Laboratory of Translational Biomedicine, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Monteiro IO; Laboratory of Translational Biomedicine, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Silveira GB; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Zaccaron RP; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Silveira PCL; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Teixeira JPF; Environmental Health Department, Portuguese National Institute of Health Dr. Ricardo Jorge, Porto, Portugal., Gajski G; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia., Andrade VM; Laboratory of Translational Biomedicine, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil. Electronic address: vmoraesdeandrade@yahoo.com.br. |
| المصدر: | Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2024 Apr; Vol. 895, pp. 503739. Date of Electronic Publication: 2024 Feb 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 1997- |
| مواضيع طبية MeSH: | Bertholletia*/chemistry , Selenium*/pharmacology , Diabetes Mellitus, Type 2*/genetics, Humans ; Overweight ; Mouth Mucosa ; Lipids ; DNA Damage ; Genomic Instability |
| مستخلص: | Type 2 diabetes mellitus (T2D) is a metabolic disease, which occurs largely due to unhealthy lifestyle. As oxidative stress is believed to promote T2D, by inducing damage to lipids, proteins, and DNA, appropriate dietary interventions seem critical to prevent, manage, and even reverse this condition. Brazil nuts (Bertholletia excelsa, H.B.K.) are nature's richest source of selenium, a mineral that has shown several health benefits. Therefore, this study aims to assess the effects of selenium consumption, through Brazil nuts, on biochemical and oxidative stress parameters, and genomic instability in T2D patients. We recruited 133 patients with T2D, registered in the Integrated Clinics of the University of Southern Santa Catarina (Brazil). Participants consumed one Brazil nut a day for six months. Blood samples and exfoliated buccal cells were collected at the beginning and the end of the intervention. The glycemic profile, lipid profile, renal profile and hepatic profile, DNA damage and selenium content were evaluated. A total of 74 participants completed the intervention. Brazil nut consumption increased selenium and GSH levels, GPx, and CAT activity while DCF and nitrites levels decreased. Total thiols increased, and protein carbonyl and MDA levels decreased. Levels of baseline and oxidative DNA damage in T2D patients were significantly decreased, as well as the frequency of micronuclei and nuclear buds. The fasting glucose levels, HDL and LDL cholesterol, and GGT levels that increased significantly in patients with type 2 diabetes were significantly reduced with nut consumption. Our results show an increase in antioxidant activity, along with reductions of protein and lipid oxidation as well as DNA damage, suggesting that Brazil nut consumption could be an ally in reducing oxidative stress and modulating the genomic instability in T2D patients. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant; Genomic instability; Health-related biomarkers; Natural products; Oxidative stress; Selenium |
| المشرفين على المادة: | H6241UJ22B (Selenium) 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20240404 Date Completed: 20240408 Latest Revision: 20240408 |
| رمز التحديث: | 20240408 |
| DOI: | 10.1016/j.mrgentox.2024.503739 |
| PMID: | 38575248 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3592 |
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| DOI: | 10.1016/j.mrgentox.2024.503739 |