دورية أكاديمية
Thromboelastometry-Based Prophylaxis for Venous Thromboembolism in the Acute Period Following Isolated Severe Traumatic Brain Injury.
| العنوان: | Thromboelastometry-Based Prophylaxis for Venous Thromboembolism in the Acute Period Following Isolated Severe Traumatic Brain Injury. |
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| المؤلفون: | Baranich AI; Neurocritical Care Department, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Sychev AA; Neurocritical Care Department, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Savin IA; Neurocritical Care Department, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Danilov GV; Laboratory of Biomedical Informatics and Artificial Intelligence, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation., Strunina YV; Laboratory of Biomedical Informatics and Artificial Intelligence, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. |
| المصدر: | Korean journal of neurotrauma [Korean J Neurotrauma] 2024 Mar 14; Vol. 20 (1), pp. 45-51. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Neurotraumatology Society Country of Publication: Korea (South) NLM ID: 101584658 Publication Model: eCollection Cited Medium: Print ISSN: 2234-8999 (Print) Linking ISSN: 22348999 NLM ISO Abbreviation: Korean J Neurotrauma Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Ch'ungbuk Ch'ŏngju-si] : Korean Neurotraumatology Society |
| مستخلص: | Objective: Traumatic brain injury (TBI) is an independent risk factor for venous thromboembolism (VTE). This study aimed to determine the optimal timing for initiating pharmacological thromboprophylaxis for VTE in patients with isolated severe TBI using rotational thromboelastometry (ROTEM). Methods: This single-center observational study enrolled 115 patients aged 18-59 years with isolated severe TBI within the first 48 hours after injury. Results: Using ROTEM data, we identified hypercoagulation due to an increase in clot density (MCF EXTEM >72), which was attributed to fibrinogen (MCF FIBTEM >25). From day 4, hypercoagulation occurred in 14.8% of the patients. By day 7, these changes were observed in 85.2% of patients. According to brain computed tomography findings, patients who received early VTE chemoprophylaxis on days 3-4 after severe TBI did not experience progression of hemorrhagic foci. Conclusion: Our results emphasize the clinical significance of thromboelastometry in patients with isolated severe traumatic TBI. Anticoagulant prophylaxis started on 3-4 days after severe TBI was relatively safe, and most patients did not experience hemorrhagic foci progression. The data acquired in this study may enable the optimization of VTE chemoprophylactic approaches, thereby reducing the associated risks to patients. Competing Interests: Conflict of Interest: The authors have no financial conflicts of interest. (Copyright © 2024 Korean Neurotraumatology Society.) |
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| فهرسة مساهمة: | Keywords: Thrombelastography; Traumatic brain injury; Venous thromboembolism |
| تواريخ الأحداث: | Date Created: 20240405 Latest Revision: 20240406 |
| رمز التحديث: | 20240406 |
| مُعرف محوري في PubMed: | PMC10990693 |
| DOI: | 10.13004/kjnt.2024.20.e10 |
| PMID: | 38576501 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2234-8999 |
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| DOI: | 10.13004/kjnt.2024.20.e10 |