دورية أكاديمية
أعرض في EDS

Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer.

التفاصيل البيبلوغرافية
العنوان: Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer.
المؤلفون: Abdel-Samed SA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt., Hozyen WG; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt., Shaaban SM; Department of Oncology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt., Hasona NA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt.
المصدر: Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2024 Apr; Vol. 39 (2), pp. 226-232. Date of Electronic Publication: 2022 Nov 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Association of Clinical Biochemists of India Country of Publication: India NLM ID: 8708303 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0970-1915 (Print) Linking ISSN: 09701915 NLM ISO Abbreviation: Indian J Clin Biochem Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2008- : New Delhi : Springer India, : Association of Clinical Biochemists of India
Original Publication: [Patna] : Association of Clinical Biochemists of India, [1986-
مستخلص: Serum microRNAs (miRs) have recently been proposed as potential cancer biomarkers for early detection. Thyroid hormones play a crucial role in human health, and their alterations are linked to a range of diseases, such as breast cancer. The relationship between NF-κβ, TNF-α, and non-coding RNAs is an urgent need for clinical trials. This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic biomarkers of breast cancer, pointing to the role of NF-κβ and TNF-α expression in miR-155 and miR-375 expression as therapeutic targets of breast cancer in the future.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
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فهرسة مساهمة: Keywords: Breast cancer; NF-κβ; TNF-α; Thyroid profile; miR-155; miR-375; microRNA
تواريخ الأحداث: Date Created: 20240405 Latest Revision: 20240406
رمز التحديث: 20240406
مُعرف محوري في PubMed: PMC10987425
DOI: 10.1007/s12291-022-01101-4
PMID: 38577133
قاعدة البيانات: MEDLINE
الوصف
تدمد:0970-1915
DOI:10.1007/s12291-022-01101-4