دورية أكاديمية
Low-dose cadmium telluride quantum dots trigger M1 polarization in macrophages through mTOR-mediated transcription factor EB activation.
| العنوان: | Low-dose cadmium telluride quantum dots trigger M1 polarization in macrophages through mTOR-mediated transcription factor EB activation. |
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| المؤلفون: | Wei T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Liu N; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Yao Y; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Huang X; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Wang Z; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Wu T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Zhang T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Xue Y; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China., Tang M; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, PR China. Electronic address: tm@seu.edu.cn. |
| المصدر: | NanoImpact [NanoImpact] 2024 Apr; Vol. 34, pp. 100505. Date of Electronic Publication: 2024 Apr 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101676795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-0748 (Electronic) Linking ISSN: 24520748 NLM ISO Abbreviation: NanoImpact Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2016]- |
| مواضيع طبية MeSH: | Tellurium*/pharmacology , Quantum Dots* , Cadmium Compounds*/pharmacology , Macrophages*/drug effects , Macrophages*/metabolism , TOR Serine-Threonine Kinases*/metabolism, Humans ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; THP-1 Cells ; Autophagy/drug effects ; Cell Differentiation/drug effects ; Signal Transduction/drug effects |
| مستخلص: | The increasing application of quantum dots (QDs) increases interactions with organisms. The inflammatory imbalance is a significant manifestation of immunotoxicity. Macrophages maintain inflammatory homeostasis. Using macrophages differentiated by phorbol 12-myristate 13-acetate-induced THP-1 cells as models, the study found that low-dose (5 μM) cadmium telluride QDs (CdTe-QDs) hindered monocyte-macrophage differentiation. CD11b is a surface marker of macrophage, and the addition of CdTe-QDs during induction resulted in a decrease in CD11b expression. Moreover, exposure of differentiated THP-1 macrophage (dTHP-1) to 5 μM CdTe-QDs led to the initiation of M1 polarization. This was indicated by the increased surface marker CD86 expression, along with elevated level of NF-κB and IL-1β proteins. The potential mechanisms are being explored. The transcription factor EB (TFEB) plays a significant role in immune regulation and serves as a crucial regulator of the autophagic lysosomal pathway. After exposed to CdTe-QDs, TFEB activation-mediated autophagy and M1 polarization were observed to occur simultaneously in dTHP-1. The mTOR signaling pathway contributed to TFEB activation induced by CdTe-QDs. However, mTOR-independent activation of TFEB failed to promote M1 polarization. These results suggest that mTOR-TFEB is an advantageous target to enhance the biocompatibility of CdTe-QDs. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autophagy; Immunoregulation; Inflammation; Quantum dots |
| المشرفين على المادة: | NQA0O090ZJ (Tellurium) 0 (Cadmium Compounds) STG188WO13 (cadmium telluride) EC 2.7.11.1 (TOR Serine-Threonine Kinases) EC 2.7.1.1 (MTOR protein, human) 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors) 0 (TFEB protein, human) |
| تواريخ الأحداث: | Date Created: 20240405 Date Completed: 20240603 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| DOI: | 10.1016/j.impact.2024.100505 |
| PMID: | 38579989 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2452-0748 |
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| DOI: | 10.1016/j.impact.2024.100505 |