دورية أكاديمية
Impact of the neurotoxin β-N-methylamino-L-alanine on the diatom Thalassiosira pseudonana using metabolomics.
| العنوان: | Impact of the neurotoxin β-N-methylamino-L-alanine on the diatom Thalassiosira pseudonana using metabolomics. |
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| المؤلفون: | Kim SY; Department of Ocean Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea., Rasmussen U; Department of Ecology, Environment and Plant Sciences, Stockholm University, SE 10691 Stockholm, Sweden., Rydberg S; Department of Ecology, Environment and Plant Sciences, Stockholm University, SE 10691 Stockholm, Sweden. Electronic address: sara.rydberg@su.se. |
| المصدر: | Marine pollution bulletin [Mar Pollut Bull] 2024 May; Vol. 202, pp. 116299. Date of Electronic Publication: 2024 Apr 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0260231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3363 (Electronic) Linking ISSN: 0025326X NLM ISO Abbreviation: Mar Pollut Bull Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Oxford : Elsevier Original Publication: London, Macmillan. |
| مواضيع طبية MeSH: | Diatoms*/drug effects , Amino Acids, Diamino* , Cyanobacteria Toxins* , Metabolomics* , Neurotoxins*/toxicity |
| مستخلص: | The neurotoxin β-N-methylamino-L-alanine (BMAA) has emerged as an environmental factor related to neurodegenerative diseases. BMAA is produced by various microorganisms including cyanobacteria and diatoms, in diverse ecosystems. In the diatom Phaeodactylum tricornutum, BMAA is known to inhibit growth. The present study investigated the impact of BMAA on the diatom Thalassiosira pseudonana by exposing it to different concentrations of exogenous BMAA. Metabolomics was predominantly employed to investigate the effect of BMAA on T. pseudonana, and MetaboAnalyst (https://www.metabo-analyst.ca/) was used to identify BMAA-associated metabolisms/pathways in T. pseudonana. Furthermore, to explore the unique response, specific metabolites were compared between treatments. When the growth was obstructed by BMAA, 17 metabolisms/pathways including nitrogen and glutathione (i.e. oxidative stress) metabolisms, were influenced in T. pseudonana. This study has further determined that 11 out of 17 metabolisms/pathways could be essentially affected by BMAA, leading to the inhibition of diatom growth. Competing Interests: Declaration of competing interest The authors declare that there is no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Algae; BMAA; Growth; Metabolomics; Toxin |
| المشرفين على المادة: | 108SA6URTV (beta-N-methylamino-L-alanine) 0 (Amino Acids, Diamino) 0 (Cyanobacteria Toxins) 0 (Neurotoxins) |
| تواريخ الأحداث: | Date Created: 20240406 Date Completed: 20240507 Latest Revision: 20240507 |
| رمز التحديث: | 20240507 |
| DOI: | 10.1016/j.marpolbul.2024.116299 |
| PMID: | 38581736 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3363 |
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| DOI: | 10.1016/j.marpolbul.2024.116299 |