دورية أكاديمية
Validation of retinal oximetry vessel selection using fluorescein angiography in patients with optic disc drusen.
| العنوان: | Validation of retinal oximetry vessel selection using fluorescein angiography in patients with optic disc drusen. |
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| المؤلفون: | Guldfeldt MU; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Pilegaard FP; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Malmqvist L; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark., Klefter ON; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Hamann S; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: mia.guldfeldt@gmail.com. |
| المصدر: | Experimental eye research [Exp Eye Res] 2024 Jun; Vol. 243, pp. 109882. Date of Electronic Publication: 2024 Apr 04. |
| نوع المنشور: | Journal Article; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: London. |
| مواضيع طبية MeSH: | Oximetry*/methods , Fluorescein Angiography*/methods , Retinal Vessels*/pathology , Retinal Vessels*/diagnostic imaging , Retinal Vessels*/physiopathology , Optic Disk Drusen*/physiopathology , Optic Disk Drusen*/diagnosis, Humans ; Female ; Male ; Cross-Sectional Studies ; Middle Aged ; Adult ; Oxygen/blood ; Reproducibility of Results ; Aged ; Oxygen Saturation/physiology ; Optic Disk/blood supply |
| مستخلص: | Retinal oximetry could provide insights into the pathophysiology of optic nerve disease, including optic disc drusen (ODD). Vessel selection for oximetry analysis is based on morphological characteristics of arterioles and venules and supported by an overlay of estimated blood oxygen saturations. The purpose of this cross-sectional study was to determine the validity of this vessel selection procedure by comparing it with vessel selection supported by video fluorescein angiography (FA). The study included 36 eyes of 36 patients with ODD who underwent retinal oximetry (Oxymap retinal oximeter T1) followed by FA (Heidelberg Spectralis). Two trained graders selected vessel segments in a pre-defined measurement area around the optic disc. One of these graders additionally performed the vessel segment selection with the support of FA images. When performed by the same grader, FA-supported and non-FA-supported vessel selection did not lead to significant differences in total vessel segment length, estimated oxygen saturations or vessel diameters (all p > 0.05). Inter-grader differences were found for arterial and venous segment lengths and arterial saturation (p < 0.05). A similar tendency was found for the arteriovenous saturation difference (p = 0.10). In conclusion, identifying vessel segments for retinal oximetry analysis based on vessel morphology and supported by a color-coded saturation overlay appears to be a valid method without the need for invasive angiography. A numerically small inter-grader variation may influence oximetry results. Further studies of retinal oximetry in ODD are warranted. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fluorescein angiography; In vivo imaging; Optic disc drusen; Oxymap; Retinal blood flow; Retinal diseases; Retinal oximetry; Retinal vessel saturation |
| تواريخ الأحداث: | Date Created: 20240406 Date Completed: 20240519 Latest Revision: 20240519 |
| رمز التحديث: | 20240520 |
| DOI: | 10.1016/j.exer.2024.109882 |
| PMID: | 38582182 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0007 |
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| DOI: | 10.1016/j.exer.2024.109882 |