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Amyloid precursor protein induces reactive astrogliosis.

التفاصيل البيبلوغرافية
العنوان: Amyloid precursor protein induces reactive astrogliosis.
المؤلفون: Velezmoro Jauregui G; Translational Ageing and Neuroscience Program, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic.; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Vukić D; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.; Faculty of Science, National Centre for Biomedical Research, Masaryk University, Brno, Czech Republic., Onyango IG; Translational Ageing and Neuroscience Program, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic., Arias C; Department of Neurosciences, University of California San Diego, La Jolla, California, USA., Novotný JS; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic., Texlová K; Translational Ageing and Neuroscience Program, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic., Wang S; Veterans Affairs San Diego Healthcare System, San Diego, USA.; Department of Anesthesia, University of California San Diego, La Jolla, California, USA., Kovačovicova KL; PsychoGenics, Paramus, New Jersey, USA., Polakova N; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic., Zelinkova J; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic., Čarna M; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic., Lacovich V; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Head BP; Veterans Affairs San Diego Healthcare System, San Diego, USA.; Department of Anesthesia, University of California San Diego, La Jolla, California, USA., Havas D; PsychoGenics, Paramus, New Jersey, USA., Mistrik M; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic., Zorec R; Laboratory of Neuroendocrinology, Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.; Celica Biomedical, Technology Park, Ljubljana, Slovenia., Verkhratsky A; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Achucarro Centre for Neuroscience, IIKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning Province, China., Keegan L; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., O'Connell MA; Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Rissman R; Department of Neurosciences, University of California San Diego, La Jolla, California, USA., Stokin GB; Translational Ageing and Neuroscience Program, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic.; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Olomouc, Czech Republic.; Department of Neurology, Gloucestershire Royal Hospital, Gloucestershire NHS Foundation Trust, Gloucester, UK.
المصدر: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2024 Jun; Vol. 240 (6), pp. e14142. Date of Electronic Publication: 2024 Apr 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-1716 (Electronic) Linking ISSN: 17481708 NLM ISO Abbreviation: Acta Physiol (Oxf) Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: Oxford : Blackwell Pub., c2006-4
مواضيع طبية MeSH: Gliosis*/metabolism , Gliosis*/pathology , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Astrocytes*/metabolism , Astrocytes*/pathology, Animals ; Mice ; Cells, Cultured ; Mice, Inbred C57BL ; Brain Injuries, Traumatic/metabolism ; Brain Injuries, Traumatic/pathology ; Mice, Knockout
مستخلص: Aim: Astrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role in reactive astrogliosis.
Methods: We investigated whether APP instigates reactive astroglios by examining in vitro and in vivo the morphology and function of naive and APP-deficient astrocytes in response to APP and well-established stressors.
Results: Overexpression of APP in cultured astrocytes led to remodeling of the intermediate filament network, enhancement of cytokine production, and activation of cellular programs centered around the interferon (IFN) pathway, all signs of reactive astrogliosis. Conversely, APP deletion abrogated remodeling of the intermediate filament network and blunted expression of IFN-stimulated gene products in response to lipopolysaccharide. Following traumatic brain injury (TBI), mouse reactive astrocytes also exhibited an association between APP and IFN, while APP deletion curbed the increase in glial fibrillary acidic protein observed canonically in astrocytes in response to TBI.
Conclusions: The APP thus represents a candidate molecular inducer and regulator of reactive astrogliosis. This finding has implications for understanding pathophysiology of neurodegenerative and other diseases of the nervous system characterized by reactive astrogliosis and opens potential new therapeutic avenues targeting APP and its pathways to modulate reactive astrogliosis.
(© 2024 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.)
التعليقات: Update of: bioRxiv. 2023 Dec 18:2023.12.18.571817. doi: 10.1101/2023.12.18.571817. (PMID: 38187544)
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معلومات مُعتمدة: (EXCELES, LX22NPO5107 (MEYS)) (G.B.S.) The European Union: Next Generation EU - Project National Institute for Neurological Research; J3-50104 (R.Z.) The Slovenian Research Agency project; 21-27329X (M.A.O. and L.K.) The Czech Science Foundation GAČR; The Slovenian Research Agency Core Research Program P3 310 Cell Physiology (R.Z.); CZ.02.1.01/0.0./15_003/0000492 (G.B.S.) The European Regional Development MAGNET; CZ02.1.01/0.0/16_019/0000868 (G.B.S.) The European Regional Development ENOCH; Interreg ITA-SLO ImmunoCluster-2; CipKeBip (R.Z.); 5I01BX003671 (B.P.H.) VA Merit Award; 1IK6BX006318 (B.P.H.) VA Research Career Scientist Award
فهرسة مساهمة: Keywords: amyloid precursor protein; astrocytes; interferon pathway; lipopolysaccharide; reactive astrogliosis; traumatic brain injury
المشرفين على المادة: 0 (Amyloid beta-Protein Precursor)
تواريخ الأحداث: Date Created: 20240408 Date Completed: 20240509 Latest Revision: 20240624
رمز التحديث: 20240624
DOI: 10.1111/apha.14142
PMID: 38584589
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-1716
DOI:10.1111/apha.14142