دورية أكاديمية
Vaccine Elicited Antibodies Restrict Glucose Availability to Control Brucella Infection.
| العنوان: | Vaccine Elicited Antibodies Restrict Glucose Availability to Control Brucella Infection. |
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| المؤلفون: | Ponzilacqua-Silva B; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA., Dadelahi AS; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA., Abushahba MFN; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA.; Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., Moley CR; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA., Skyberg JA; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Apr 08. Date of Electronic Publication: 2024 Apr 08. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مستخلص: | The impact of vaccine-induced immune responses on host metabolite availability has not been well studied. Here we show prior vaccination alters the metabolic profile of mice challenged with Brucella melitensis. In particular, glucose levels were reduced in vaccinated mice in an antibody-dependent manner. We also found the glucose transporter gene, gluP, plays a lesser role in B. melitensis virulence in vaccinated wild-type mice relative to vaccinated mice unable to secrete antibodies. These data indicate vaccine-elicited antibodies protect the host in part by restricting glucose availability. Moreover, Brucella and other pathogens may need to employ different metabolic strategies in vaccinated hosts. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| معلومات مُعتمدة: | R01 AI150797 United States AI NIAID NIH HHS; R21 AI146397 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Brucella; antibody; brucellosis; glucose; metabolism; vaccine |
| تواريخ الأحداث: | Date Created: 20240408 Latest Revision: 20240521 |
| رمز التحديث: | 20240521 |
| DOI: | 10.1093/infdis/jiae172 |
| PMID: | 38586904 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae172 |