دورية أكاديمية
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ACL5 acquired strict thermospermine synthesis activity during the emergence of vascular plants.

التفاصيل البيبلوغرافية
العنوان: ACL5 acquired strict thermospermine synthesis activity during the emergence of vascular plants.
المؤلفون: Takahashi Y; Department of Life Science, Faculty of Life Science, Kyushu Sangyo University, 2-3-1 Matsukadai Higashi-ku, Fukuoka, 813-8503, Japan.
المصدر: The New phytologist [New Phytol] 2024 Jun; Vol. 242 (6), pp. 2669-2681. Date of Electronic Publication: 2024 Apr 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley on behalf of New Phytologist Trust
Original Publication: London, New York [etc.] Academic Press.
مواضيع طبية MeSH: Spermine*/metabolism , Spermine*/analogs & derivatives, Substrate Specificity ; Phylogeny ; Nicotiana/genetics ; Nicotiana/metabolism ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Gene Expression Regulation, Plant ; Amino Acid Sequence
مستخلص: Norspermine (Nspm), one of the uncommon polyamines (PAs), was detected in bryophytes and lycophytes; therefore, the aminopropyltransferases involved in the synthesis of Nspm were investigated. The enzymatic activity was evaluated by the transient high expression of various aminopropyltransferase genes in Nicotiana benthamiana, followed by quantification of PA distribution in the leaves using gas chromatography-mass spectrometry. The bryophyte orthologues of ACL5, which is known to synthesise thermospermine (Tspm) in flowering plants, were found to have strong Nspm synthesis activity. In addition, two ACL5 orthologous with different substrate specificities were conserved in Selaginella moellendorffii, one of which was involved in Tspm synthesis and the other in Nspm synthesis. Therefore, further detailed analysis using these two factors revealed that the β-hairpin structural region consisting of β-strands 1 and 2 at the N-terminus of ACL5 is involved in substrate specificity. Through functional analysis of a total of 40 ACL5 genes in 33 organisms, including algae, it was shown that ACL5 has changed its substrate specificity several times during plant evolution and diversification. Furthermore, it was strongly suggested that ACL5 acquired strict Tspm synthesis activity during the emergence of vascular plants, especially through major changes around the β-hairpin structural region.
(© 2024 The Authors New Phytologist © 2024 New Phytologist Foundation.)
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معلومات مُعتمدة: JP23K05231 JSPS KAKENHI
فهرسة مساهمة: Keywords: ACL5; Selaginella moellendorffii; aminopropyltransferase; norspermine; polyamine; substrate specificity; thermospermine
المشرفين على المادة: 70862-11-2 (thermospermine)
2FZ7Y3VOQX (Spermine)
0 (Plant Proteins)
تواريخ الأحداث: Date Created: 20240408 Date Completed: 20240523 Latest Revision: 20240523
رمز التحديث: 20240523
DOI: 10.1111/nph.19733
PMID: 38587066
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-8137
DOI:10.1111/nph.19733