دورية أكاديمية
Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis.
| العنوان: | Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis. |
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| المؤلفون: | Hadidi MF; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alhamami N; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alhakami M; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Abdulhamid AS; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. Abdulhamid018@ksau-hs.edu.sa.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Abdulhamid018@ksau-hs.edu.sa., Alsharif A; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alomari MS; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alghamdi YA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alshehri S; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Ghaddaf AA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Alsenani FM; Department of Urology, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia., Almadani H; Department of Urology, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia. |
| المصدر: | World journal of urology [World J Urol] 2024 Apr 08; Vol. 42 (1), pp. 221. Date of Electronic Publication: 2024 Apr 08. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Berlin ; New York] : Springer International, 1983- |
| مواضيع طبية MeSH: | Fosfomycin*/therapeutic use , Urinary Tract Infections*/drug therapy, Humans ; Anti-Bacterial Agents/therapeutic use ; Nitrofurantoin ; Trimethoprim, Sulfamethoxazole Drug Combination ; Network Meta-Analysis ; Ciprofloxacin/therapeutic use ; Recurrence |
| مستخلص: | Purpose: Fosfomycin has been used more frequently in managing uncomplicated urinary tract infections (UTIs) due to decreased compliance and increased multidrug-resistant bacteria. The aim of this network meta-analysis was to assess the efficacy of Fosfomycin compared to Nitrofurantoin, Trimethoprim-Sulfamethoxazole (TMP-SMX), and Ciprofloxacin in terms of clinical and microbiological cure alongside with other measurements. Materials and Methods: We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). We included randomized control trials (RCTs) with uncomplicated UTI patients who received Fosfomycin, Nitrofurantoin, TMP-SMX, or Ciprofloxacin and reported the clinical or microbiological cure. We used Cochrane Risk of Bias Assessment Tool to assess the included studies' quality. R-software was used for all statistical analysis. We ranked all antibiotics using the netrank function which yielded P scores. Frequentist network meta-analysis was used to assess the efficacy of all outcomes. Results: We included 13 RCTs with a total number of 3856 patients that showed Fosfomycin ranked the highest among the other antibiotics with respect to clinical cure (P-score = 0.99) and microbiological cure (P-score = 0.99) while Ciprofloxacin ranked the lowest (P-score = 0.11 and 0.02, respectively). Moreover, Ciprofloxacin yielded the highest relapse rate (P-score = 1), whereas TMP-SMX had the lowest relapse rate (P-score = 0.07). As for the adverse events, Ciprofloxacin demonstrated the highest adverse events as opposed to Fosfomycin (P-score = 0.98 and 0.05, respectively). Conclusion: The network meta-analysis demonstrated that Fosfomycin is the most effective antibiotic in treating uncomplicated UTIs with respect to clinical cure, microbiological cure, and adverse events profile. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| التعليقات: | Comment in: World J Urol. 2024 Apr 24;42(1):253. (PMID: 38656369) |
| References: | Wagenlehner FM, Hoyme U, Kaase M, Fünfstück R, Naber KG, Schmiemann G (2011) Uncomplicated urinary tract infections. Dtsch Arztebl Int 108(24):415. (PMID: 217763113132618) Ceran N, Mert D, Kocdogan FY, Erdem I, Ozyurek S, Goktas P, Adalati R (2010) A randomized comparative study of single-dose fosfomycin and 5-day ciprofloxacin in female patients with uncomplicated lower urinary tract infections. J Infect Chemother 16(6):424–430. (PMID: 10.1007/s10156-010-0079-z20585969) Bono MJ, Leslie SW, Reygaert WC (2023) Uncomplicated urinary tract infections. In: StatPearls. StatPearls Publishing, Treasure Island (FL), PMID: 29261874. Rowe TA, Juthani-Mehta M (2013) Urinary tract infection in older adults. Aging health 9(5):519–528. (PMID: 10.2217/ahe.13.38) European Association of Urology (2023) EAU guidelines on urological infections. Waller TA, Pantin SA, Yenior AL, Pujalte GG (2018) Urinary tract infection antibiotic resistance in the United States. Prim Care 45(3):455–466. (PMID: 10.1016/j.pop.2018.05.00530115334) Falagas ME, Kotsantis IK, Vouloumanou EK, Rafailidis PI (2009) Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a meta-analysis of randomized controlled trials. J Infect 58(2):91–102. (PMID: 10.1016/j.jinf.2008.12.00919195714) Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, Moran GJ, Nicolle LE, Raz R, Schaeffer AJ, Soper DE (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52(5):e103–e120. (PMID: 10.1093/cid/ciq25721292654) Falagas ME, Vouloumanou EK, Togias AG, Karadima M, Kapaskelis AM, Rafailidis PI, Athanasiou S (2010) Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials. J Antimicrob Chemother 65(9):1862–1877. (PMID: 10.1093/jac/dkq23720587612) Ten Doesschate T, Kuiper S, van Nieuwkoop C, Hassing RJ, Ketels T, van Mens SP, van den Bijllaardt W, van der Bij AK, Geerlings SE, Koster A, Koldewijn EL (2022) Fosfomycin vs. ciprofloxacin as oral step-down treatment for Escherichia coli febrile urinary tract infections in women: a randomized, placebo-controlled, double-blind, multicenter trial. Clin Infect Dis 75(2):221–229. (PMID: 10.1093/cid/ciab93434791074) Konwar M, Gogtay NJ, Ravi R, Thatte UM, Bose D (2022) Evaluation of efficacy and safety of fosfomycin versus nitrofurantoin for the treatment of uncomplicated lower urinary tract infection (UTI) in women—a systematic review and meta-analysis. J Chemother 34(3):139–148. (PMID: 10.1080/1120009X.2021.193894934151754) Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1–e34. (PMID: 10.1016/j.jclinepi.2009.06.00619631507) Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. (PMID: 10.1136/bmj.l489831462531) Arredondo-García JL, Figueroa-Damián R, Rosas A, Jáuregui A, Corral M, Costa A, Merlos RM, Ríos-Fabra A, Amábile-Cuevas CF, Hernández-Oliva GM, Olguín J (2004) Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: a randomized, multicentre, open-label, prospective study. J Antimicrob Chemother 54(4):840–843. (PMID: 10.1093/jac/dkh41415347634) Crocchiolo P (1990) Single-dose fosfomycin trometamol versus multiple-dose cotrimoxazole in the treatment of lower urinary tract infections in general practice. Chemotherapy 36(suppl 1):37–40. (PMID: 10.1159/0002388152085988) Hassan MM, Malik M, Saleem R, Saleem A, Zohaib K, Malik AY, Javaid M (2022) Efficacy of single dose of fosfomycin versus a 5-day course of ciprofloxacin in patients with uncomplicated urinary tract infection. Cureus 14(5):e24843. (PMID: 357024509177222) Henry NK, Schultz HJ, Grubbs NC, Muller SM, Ilstrup DM, Wilson WR (1986) Comparison of ciprofloxacin and co-trimoxazole in the treatment of uncomplicated urinary tract infection in women. J Antimicrob Chemother 18(suppl D):103–106. (PMID: 10.1093/jac/18.Supplement_D.1033492486) Hooton TM, Winter C, Tiu F, Stamm WE (1995) Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women. JAMA 273(1):41–45. (PMID: 10.1001/jama.1995.035202500570347654268) Huttner A, Kowalczyk A, Turjeman A, Babich T, Brossier C, Eliakim-Raz N, Kosiek K, De Tejada BM, Roux X, Shiber S, Theuretzbacher U (2018) Effect of 5-day nitrofurantoin vs. single-dose fosfomycin on clinical resolution of uncomplicated lower urinary tract infection in women: a randomized clinical trial. JAMA 319(17):1781–1789. (PMID: 10.1001/jama.2018.3627297102956134435) Urinary Tract Infection Group, Iravani A, Klimberg I, Briefer C, Munera C, Kowalsky SF, Echols RM (1999) A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection. J Antimicrob Chemother 43(suppl 1):67–75. (PMID: 10.1093/jac/43.suppl_1.67) McCarty JM, Richard G, Huck W, Tucker RM, Tosiello RL, Shan M, Heyd A, Echols RM (1999) A randomized trial of short-course ciprofloxacin, ofloxacin, or trimethoprim/sulfamethoxazole for the treatment of acute urinary tract infection in women. Am J Med 106(3):292–299. (PMID: 10.1016/S0002-9343(99)00026-110190377) Naber KG, Thyroff-Friesinger U (1992) Spectrum and susceptibility of pathogens causing acute uncomplicated lower UTI in females and its correlation to bacteriologic outcome after single dose therapy with fosfomycin trometamol versus ofloxacin/co-trimoxazole. Infection 20(suppl 4):S296–S301. (PMID: 10.1007/BF017100181294521) Van Pienbroek E, Hermans J, Kaptein AA, Mulder JD (1993) Fosfomycin trometamol in a single dose versus 7 days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women. Pharm World Sci 15:257–262. (PMID: 10.1007/BF018711278298585) Spencer RC, Moseley DJ, Greensmith MJ (1994) Nitrofurantoin modified release versus trimetfaoprim or co-trimoxazole in the treatment of uncomplicated urinary tract infection in general practice. J Antimicrob Chemother 33(suppl A):121–129. (PMID: 10.1093/jac/33.suppl_A.1217928829) Stein GE (1999) Comparison of single-dose fosfomycin and a 7-day course of nitrofurantoin in female patients with uncomplicated urinary tract infection. Clin Ther 21(11):1864–1872. (PMID: 10.1016/S0149-2918(00)86734-X10890258) Falagas ME, Vouloumanou EK, Samonis G, Vardakas KZ (2016) Fosfomycin. Clin Microbiol Rev 29(2):321–347. (PMID: 10.1128/CMR.00068-15269609384786888) Hooton TM (2012) Uncomplicated urinary tract infection. N Engl J Med 366(11):1028–1037. (PMID: 10.1056/NEJMcp110442922417256) Silver LL (2017) Fosfomycin: mechanism and resistance. Cold Spring Harb Perspect Med 7(2):a025262. (PMID: 10.1101/cshperspect.a025262280625575287057) Kot B (2019) Antibiotic resistance among uropathogenic. Pol J Microbiol 68(4):403–415. (PMID: 10.33073/pjm-2019-048318808857260639) Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE (1999) Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Clin Infect Dis 29(4):745–759. (PMID: 10.1086/52042710589881) Sadler S, Holmes M, Ren S, Holden S, Jha S, Thokala P (2017) Cost-effectiveness of antibiotic treatment of uncomplicated urinary tract infection in women: a comparison of four antibiotics. BJGP Open 1(3):bjgpopen17X101097. (PMID: 10.3399/bjgpopen17X101097305646816169925) Perrault L, Dahan S, Iliza AC, LeLorier J, Zhanel GG (2017) Cost-effectiveness analysis of fosfomycin for treatment of uncomplicated urinary tract infections in Ontario. Can J Infect Dis Med Microbiol 2017:6362804. (PMID: 10.1155/2017/6362804283166325337864) Wang T, Wu G, Wang J, Cui Y, Ma J, Zhu Z, Qiu J, Wu J (2020) Comparison of single-dose fosfomycin tromethamine and other antibiotics for lower uncomplicated urinary tract infection in women and asymptomatic bacteriuria in pregnant women: a systematic review and meta-analysis. Int J Antimicrob Agents 56(1):106018. (PMID: 10.1016/j.ijantimicag.2020.10601832417205) |
| فهرسة مساهمة: | Keywords: Ciprofloxacin; Fosfomycin; Nitrofurantoin; Trimethoprim–Sulfamethoxazole; Urinary tract infection |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 2N81MY12TE (Fosfomycin) 927AH8112L (Nitrofurantoin) 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination) 5E8K9I0O4U (Ciprofloxacin) |
| تواريخ الأحداث: | Date Created: 20240408 Date Completed: 20240409 Latest Revision: 20240424 |
| رمز التحديث: | 20240424 |
| DOI: | 10.1007/s00345-024-04922-5 |
| PMID: | 38587648 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-8726 |
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| DOI: | 10.1007/s00345-024-04922-5 |