دورية أكاديمية
أعرض في EDS

Association of Speckle-Based Blood Flow Measurements and Fluorescein Angiography in Infants with Retinopathy of Prematurity.

التفاصيل البيبلوغرافية
العنوان: Association of Speckle-Based Blood Flow Measurements and Fluorescein Angiography in Infants with Retinopathy of Prematurity.
المؤلفون: Shats D; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Balasubramanian T; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Sidelnikov D; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Das U; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Onyekaba NA; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Forbes HE; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Lu N; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Williams K; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Levin MR; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Sundararajan S; Department of Neonatology, University of Maryland School of Medicine, Baltimore, Maryland., Vij S; Vasoptic Medical, Inc., Columbia, Maryland., Gadagkar H; Vasoptic Medical, Inc., Columbia, Maryland., Rege A; Vasoptic Medical, Inc., Columbia, Maryland., Saeedi O; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Chen V; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland., Alexander JL; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
المصدر: Ophthalmology science [Ophthalmol Sci] 2023 Dec 29; Vol. 4 (4), pp. 100463. Date of Electronic Publication: 2023 Dec 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier, B.V., [2021]-
مستخلص: Purpose: To determine the correlation between blood flow metrics measured by intravenous fluorescein angiography (IVFA) and the blood flow velocity index (BFVi) obtained by laser speckle contrast imaging (LSCI) in infants with retinopathy of prematurity (ROP).
Design: Prospective comparative pilot study.
Subjects: Seven eyes from 7 subjects with ROP.
Methods: Unilateral LSCI and IVFA data were obtained from each subject in the neonatal intensive care unit. Five LSCI-based metrics and 5 IVFA-based metrics were extracted from images to quantify blood flow patterns in the same region of interest. Correlation between LSCI-based and IVFA-based blood flow metrics was compared between 2 subgroups of ROP severity: moderate ROP (defined as stage ≤ 2 without Plus disease) and severe ROP (defined as stage ≥3 or Plus disease).
Main Outcome Measures: Pearson and Kendall rank correlation coefficients between IVFA and LSCI metrics; Student t test P values comparing LSCI metrics between "severe" and "moderate" ROP groups.
Results: Pearson correlations between IVFA and LSCI included arterial-venous transit time (AVTT) and peak BFVi (pBFVi; r  = -0.917; P  = 0.004), AVTT and dip BFVi (dBFVi; r  = -0.920; P  = 0.003), AVTT and mean BFVi ( r  = -0.927- P  = 0.003), and AVTT and volumetric rise index ( r  = -0.779; P  = 0.039). Kendall rank correlation between AVTT and dBFVi was r  = -0.619 ( P  = 0.051). pBFVi was higher in severe ROP than in moderate ROP (8.4 ± 0.6 and 4.4 ± 1.8, respectively; P  = 0.0045 using the 2-sample t test with pooled variance and P  = 0.0952 using the Wilcoxon rank-sum test).
Conclusions: Correlation was found between blood flow metrics obtained by IVFA and noninvasive LSCI techniques. We demonstrate the feasibility of obtaining quantitative metrics using LSCI in infants with ROP in this pilot study; however, further investigation is needed to evaluate its potential use in clinical assessment of ROP severity.
Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
(© 2024 by the American Academy of Ophthalmology.)
References: BMC Ophthalmol. 2016 Apr 05;16:36. (PMID: 27044276)
BMC Pediatr. 2012 Aug 28;12:132. (PMID: 22928523)
Curr Eye Res. 2016 Nov;41(11):1447-1453. (PMID: 27159148)
Eye (Lond). 2022 Aug;36(8):1604-1609. (PMID: 34290444)
Transl Vis Sci Technol. 2018 Nov 14;7(6):7. (PMID: 30479878)
JAMA Ophthalmol. 2017 Dec 1;135(12):1430-1433. (PMID: 29098279)
Clin Ophthalmol. 2012;6:1369-71. (PMID: 22942640)
Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1631-1636. (PMID: 27118037)
Pak J Med Sci. 2017 Nov-Dec;33(6):1328-1332. (PMID: 29492053)
Case Rep Ophthalmol. 2017 Feb 2;8(1):91-98. (PMID: 28413406)
J Biomed Opt. 2019 Aug;24(8):1-11. (PMID: 31385481)
Klin Monbl Augenheilkd. 1991 Nov;199(5):325-9. (PMID: 1787654)
Transl Vis Sci Technol. 2021 Feb 5;10(2):22. (PMID: 34003907)
Ophthalmol Retina. 2019 May;3(5):436-443. (PMID: 31044736)
Ophthalmology. 2011 Jan;118(1):168-75. (PMID: 20709401)
Br J Ophthalmol. 2002 Apr;86(4):429-33. (PMID: 11914213)
Sci Rep. 2020 Nov 19;10(1):20236. (PMID: 33214571)
BMJ Case Rep. 2021 Jul 27;14(7):. (PMID: 34315751)
PLoS One. 2017 Mar 29;12(3):e0174427. (PMID: 28355247)
Klin Oczna. 2006;108(1-3):32-5. (PMID: 16883936)
Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2241-2247. (PMID: 29980917)
Eur J Ophthalmol. 2013 Nov-Dec;23(6):881-6. (PMID: 23709330)
Ophthalmology. 2015 Aug;122(8):1601-8. (PMID: 26028345)
JAMA Ophthalmol. 2021 May 01;139(5):567-574. (PMID: 33792625)
Graefes Arch Clin Exp Ophthalmol. 2008 Aug;246(8):1147-52. (PMID: 18386036)
J Perinatol. 2015 Sep;35(9):745-7. (PMID: 25950917)
Ophthalmol Glaucoma. 2022 May-Jun;5(3):250-261. (PMID: 34673279)
J AAPOS. 1999 Aug;3(4):194-8. (PMID: 10477220)
Egypt Heart J. 2018 Sep;70(3):167-171. (PMID: 30190642)
Ophthalmology. 2022 Jul;129(7):e69-e76. (PMID: 35157950)
Jpn J Ophthalmol. 2017 Nov;61(6):484-493. (PMID: 28932922)
Ophthalmology. 2023 Sep;130(9):907-913. (PMID: 37037315)
Acta Ophthalmol. 2022 Feb;100(1):e128-e134. (PMID: 34939742)
معلومات مُعتمدة: K23 EY032525 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: Blood flow; Intravenous fluorescein angiography; Laser speckle contrast imaging; Laser speckle flowgraphy; Retinopathy of prematurity
تواريخ الأحداث: Date Created: 20240409 Latest Revision: 20240509
رمز التحديث: 20240509
مُعرف محوري في PubMed: PMC11000102
DOI: 10.1016/j.xops.2023.100463
PMID: 38591050
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-9145
DOI:10.1016/j.xops.2023.100463