دورية أكاديمية
Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha.
العنوان: | Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha. |
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المؤلفون: | Kaur K; Department of Pharmaceutical Sciences and Natural Products. Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Verma H; Department of Zoology, Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Gangwar P; Department of Zoology, Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Jangid K; Department of Chemistry, Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Dhiman M; Department of Microbiology, Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Kumar V; Department of Chemistry, Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India., Jaitak V; Department of Pharmaceutical Sciences and Natural Products. Central University of Punjab, Ghudda, Bathinda (Pb) 151401, India. Electronic address: vikasjaitak@gmail.com. |
المصدر: | Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107341. Date of Electronic Publication: 2024 Apr 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
مواضيع طبية MeSH: | Estrogen Receptor alpha*/metabolism , Estrogen Receptor alpha*/antagonists & inhibitors , Indoles*/chemistry , Indoles*/pharmacology , Indoles*/chemical synthesis , Oxadiazoles*/chemistry , Oxadiazoles*/pharmacology , Oxadiazoles*/chemical synthesis , Drug Design* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Cell Proliferation*/drug effects , Drug Screening Assays, Antitumor* , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Cell Line, Tumor |
مستخلص: | A series of new indole-oxadiazole derivatives was designed and synthesized to develop potential anti-breast cancer agents. The compounds exhibited significant inhibitory activity with IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Anti-cancer; Breast Cancer; Estrogen receptor; Indole; Oxadiazole; Western blot |
المشرفين على المادة: | 0 (ESR1 protein, human) |
تواريخ الأحداث: | Date Created: 20240409 Date Completed: 20240516 Latest Revision: 20240516 |
رمز التحديث: | 20240517 |
DOI: | 10.1016/j.bioorg.2024.107341 |
PMID: | 38593531 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2120 |
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DOI: | 10.1016/j.bioorg.2024.107341 |