دورية أكاديمية
Microstructural, Micromechanical Atlas of the Temporomandibular Joint Disc.
| العنوان: | Microstructural, Micromechanical Atlas of the Temporomandibular Joint Disc. |
|---|---|
| المؤلفون: | Jiang N; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Tan P; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Sun Y; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Zhou J; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Ren R; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Li Z; Ao Research Institute Davos, Davos, Graubünden, Switzerland., Zhu S; State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. |
| المصدر: | Journal of dental research [J Dent Res] 2024 May; Vol. 103 (5), pp. 555-564. Date of Electronic Publication: 2024 Apr 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 0354343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-0591 (Electronic) Linking ISSN: 00220345 NLM ISO Abbreviation: J Dent Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Original Publication: Chicago, American Dental Assn. [etc.] |
| مواضيع طبية MeSH: | Temporomandibular Joint Disc*/physiopathology, Animals ; Rabbits ; Swine ; Biomechanical Phenomena ; Collagen ; Stress, Mechanical ; Disease Models, Animal ; Temporomandibular Joint Disorders/physiopathology ; Temporomandibular Joint Disorders/pathology |
| مستخلص: | The temporomandibular joint (TMJ) disc is mainly composed of collagen, with its arrangement responding to efficient stress distribution. However, microstructural and micromechanical transformations of the TMJ disc under resting, functional, and pathological conditions remain unclear. To address this, our study presents a high-resolution microstructural and mechanical atlas of the porcine TMJ disc. First, the naive microstructure and mechanical properties were investigated in porcine TMJ discs (resting and functional conditions). Subsequently, the perforation and tear models (pathological conditions) were compared. Following this, a rabbit model of anterior disc displacement (abnormal stress) was studied. Results show diverse microstructures and mechanical properties at the nanometer to micrometer scale. In the functional state, gradual unfolding of the crimping cycle in secondary and tertiary structures leads to D-cycle prolongation in the primary structure, causing tissue failure. Pathological conditions lead to stress concentration near the injury site due to collagen interfibrillar traffic patterns, resulting in earlier damage manifestation. Additionally, the abnormal stress model shows collagen damage initiating at the primary structure and extending to the superstructure over time. These findings highlight collagen's various roles in different pathophysiological states. Our study offers valuable insights into TMJ disc function and dysfunction, aiding the development of diagnostic and therapeutic strategies for TMJ disorders, as well as providing guidance for the design of structural biomimetic materials. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: atomic force microscopy; collagen; hierarchical structure; mechanical behavior; structural transformation; temporomandibular disorders |
| المشرفين على المادة: | 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20240409 Date Completed: 20240426 Latest Revision: 20240426 |
| رمز التحديث: | 20240426 |
| DOI: | 10.1177/00220345241227822 |
| PMID: | 38594786 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1544-0591 |
|---|---|
| DOI: | 10.1177/00220345241227822 |