دورية أكاديمية
Facile construction of gefitinib-loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells.
العنوان: | Facile construction of gefitinib-loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells. |
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المؤلفون: | Aiyasamy K; Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode, Namakkal, Tamil Nadu, India., Ramasamy M; Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode, Namakkal, Tamil Nadu, India., Hirad AH; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Arulselvan P; Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India., Jaganathan R; Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Perak, Malaysia., Suriyaprakash J; Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China., Thangavelu I; Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India., Alarfaj AA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia. |
المصدر: | Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2024 Aug; Vol. 71 (4), pp. 896-908. Date of Electronic Publication: 2024 Apr 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8609465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8744 (Electronic) Linking ISSN: 08854513 NLM ISO Abbreviation: Biotechnol Appl Biochem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Jan. 2011- : Malden : Wiley-Blackwell Original Publication: San Diego : Academic Press, [cl986]- |
مواضيع طبية MeSH: | Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Zeolites*/chemistry , Zeolites*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Nanocomposites*/chemistry , Gefitinib*/pharmacology , Gefitinib*/chemistry, Humans ; Cell Proliferation/drug effects ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/pharmacology ; Metal-Organic Frameworks/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Cell Line, Tumor ; A549 Cells |
مستخلص: | Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In preclinical trials, several lung cancer cell lines and xenografts have demonstrated potential activity with GET. Response rates neared 25% in preclinical trials for non-small cell lung cancer. Here, we describe the one-pot synthesis of GET@ZIF-8 nanocomposites (NCs) in pure water, encapsulating zeolitic imidazolate framework 8 (ZIF-8). This method developed NCs with consistent morphology and a loading efficiency of 9%, resulting in a loading capacity of 20 wt%. Cell proliferation assay assessed the anticancer effect of GET@ZIF-8 NCs on A549 and H1299 cells. The different biochemical staining (Calcein-AM and PI and 4',6-Diamidino-2-phenylindole nuclear staining) assays assessed the cell death and morphological examination. Additionally, the mode of apoptosis was evaluated by mitochondrial membrane potential (∆ψm) and reactive oxygen species. Therefore, the study concludes that GET@ZIF-8 NCs are pledged to treat lung cancer cells. (© 2024 International Union of Biochemistry and Molecular Biology, Inc.) |
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فهرسة مساهمة: | Keywords: apoptosis; gefitinib; lung cancer; nanocomposites; zeolitic imidazolate framework |
المشرفين على المادة: | 1318-02-1 (Zeolites) 0 (Antineoplastic Agents) S65743JHBS (Gefitinib) 0 (Metal-Organic Frameworks) 0 (Imidazoles) |
تواريخ الأحداث: | Date Created: 20240410 Date Completed: 20240807 Latest Revision: 20240807 |
رمز التحديث: | 20240808 |
DOI: | 10.1002/bab.2585 |
PMID: | 38594878 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1470-8744 |
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DOI: | 10.1002/bab.2585 |