دورية أكاديمية
[A unicenter real-world study of the correlation factors for complete clinical response in idiopathic inflammatory myopathies].
| العنوان: | [A unicenter real-world study of the correlation factors for complete clinical response in idiopathic inflammatory myopathies]. |
|---|---|
| المؤلفون: | Lai Z; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Li J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Yun Z; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Zhang Y; Department of Rheumatology and Immunology, Baoding First Hospital, Baoding 071000, Hebei, China., Zhang H; Department of Rheumatology and Immunology, Dalian Municipal Central Hospital, Dalian 116089, Liaoning, China., Xing X; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Shao M; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Jin Y; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Wang N; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Li Y; Department of Rheumatology and Immunology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Li Y; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China., Li Z; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China. |
| المصدر: | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2024 Apr 18; Vol. 56 (2), pp. 284-292. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print) Linking ISSN: 1671167X NLM ISO Abbreviation: Beijing Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Beijing da xue, 2001- |
| مواضيع طبية MeSH: | Hyperferritinemia* , Myositis*/diagnosis , Lung Diseases, Interstitial* , Autoimmune Diseases*, Humans ; Autoantibodies ; Pathologic Complete Response ; Retrospective Studies |
| مستخلص: | Objective: To investigate the correlation factors of complete clinical response in idiopathic inflammatory myopathies (IIMs) patients receiving conventional treatment. Methods: Patients diagnosed with IIMs hospitalized in Peking University People's Hospital from January 2000 to June 2023 were included. The correlation factors of complete clinical response to conventional treatment were identified by analyzing the clinical characteristics, laboratory features, peripheral blood lymphocytes, immunological indicators, and therapeutic drugs. Results: Among the 635 patients included, 518 patients finished the follow-up, with an average time of 36.8 months. The total complete clinical response rate of IIMs was 50.0% (259/518). The complete clinical response rate of dermatomyositis (DM), anti-synthetase syndrome (ASS) and immune-mediated necrotizing myopathy (IMNM) were 53.5%, 48.9% and 39.0%, respectively. Fever ( P =0.002) and rapid progressive interstitial lung disease (RP-ILD) ( P =0.014) were observed much more frequently in non-complete clinical response group than in complete clinical response group. The aspartate transaminase (AST), lactate dehydrogenase (LDH), D-dimer, erythrocyte sedimentation rate (ESR), C-reaction protein (CRP) and serum ferritin were significantly higher in non-complete clinical response group as compared with complete clinical response group. As for the treatment, the percentage of glucocorticoid received and intravenous immunoglobin (IVIG) were significantly higher in non-complete clinical response group than in complete clinical response group. Risk factor analysis showed that IMNM subtype ( P =0.007), interstitial lung disease (ILD) ( P =0.001), eleva-ted AST ( P =0.012), elevated serum ferritin ( P =0.016) and decreased count of CD4 + T cells in peripheral blood ( P =0.004) might be the risk factors for IIMs non-complete clinical response. Conclusion: The total complete clinical response rate of IIMs is low, especially for IMNM subtype. More effective intervention should be administered to patients with ILD, elevated AST, elevated serum ferritin or decreased count of CD4 + T cells at disease onset. |
| References: | Int J Clin Pract. 2021 Oct;75(10):e14615. (PMID: 34235806) Clin Exp Rheumatol. 2023 Mar;41(2):309-315. (PMID: 36826791) Curr Rheumatol Rep. 2018 Mar 26;20(4):21. (PMID: 29582188) Rheumatology (Oxford). 2017 May 1;56(5):787-794. (PMID: 28096458) Arthritis Care Res (Hoboken). 2023 May;75(5):1175-1182. (PMID: 35921214) Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Dec 18;51(6):989-995. (PMID: 31848492) Neuromuscul Disord. 2018 Jan;28(1):87-99. (PMID: 29221629) Rheumatology (Oxford). 2002 Jan;41(1):22-6. (PMID: 11792875) Arthritis Rheumatol. 2017 Dec;69(12):2271-2282. (PMID: 29106061) Semin Arthritis Rheum. 2019 Dec;49(3):420-429. (PMID: 31109639) Best Pract Res Clin Rheumatol. 2020 Aug;34(4):101503. (PMID: 32284267) JAMA Neurol. 2018 Dec 1;75(12):1528-1537. (PMID: 30208379) J Neurol Neurosurg Psychiatry. 2016 Oct;87(10):1038-44. (PMID: 27147697) J Rheumatol. 1985 Dec;12(6):1140-8. (PMID: 4093921) Beijing Da Xue Xue Bao Yi Xue Ban. 2021 Dec 18;53(6):1078-1082. (PMID: 34916685) J Am Acad Dermatol. 2020 Feb;82(2):267-281. (PMID: 31279808) Ther Adv Musculoskelet Dis. 2020 Oct 16;12:1759720X20936822. (PMID: 33133243) Clin Rheumatol. 2009 Jun;28(6):639-46. (PMID: 19247576) Semin Immunopathol. 2012 Jan;34(1):43-62. (PMID: 22037947) Rheumatology (Oxford). 2020 Mar 1;59(3):586-593. (PMID: 31410476) Int J Rheum Dis. 2018 Feb;21(2):487-496. (PMID: 29314762) Ther Adv Chronic Dis. 2022 May 13;13:20406223221098128. (PMID: 35586303) Autoimmun Rev. 2022 Feb;21(2):102993. (PMID: 34798316) Medicine (Baltimore). 1977 Jul;56(4):255-86. (PMID: 327194) Rheumatol Int. 2012 Dec;32(12):3909-15. (PMID: 22198664) J Immunol Res. 2020 Nov 25;2020:2024869. (PMID: 33299896) JAMA Dermatol. 2018 Jan 1;154(1):44-51. (PMID: 29114741) J Neurol Sci. 2019 Feb 15;397:123-128. (PMID: 30616054) Front Immunol. 2021 Sep 23;12:729602. (PMID: 34630407) Nat Rev Dis Primers. 2021 Dec 2;7(1):86. (PMID: 34857798) Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Apr 18;42(2):140-2. (PMID: 20396351) Semin Respir Crit Care Med. 2014 Apr;35(2):239-48. (PMID: 24668538) Ann Rheum Dis. 2017 May;76(5):792-801. (PMID: 28385805) N Engl J Med. 1975 Feb 13;292(7):344-7. (PMID: 1090839) Eur J Radiol. 2015 Mar;84(3):516-523. (PMID: 25541020) Chest. 2023 Jun;163(6):1476-1491. (PMID: 36764512) Lung. 2016 Oct;194(5):733-7. (PMID: 27166633) Arthritis Rheum. 2005 Sep;52(9):2607-15. (PMID: 16142757) Rheumatol Int. 2016 Jul;36(7):935-43. (PMID: 27193471) Curr Opin Neurol. 2019 Oct;32(5):704-714. (PMID: 31369423) N Engl J Med. 1975 Feb 20;292(8):403-7. (PMID: 1089199) Front Med (Lausanne). 2020 Jul 31;7:363. (PMID: 32850886) Front Med (Lausanne). 2022 Jun 15;9:908365. (PMID: 35783655) Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S118-57. (PMID: 22588740) |
| فهرسة مساهمة: | Keywords: Autoantibodies; Clinical response; Idiopathic inflammatory myopathies; Interstitial lung disease; Risk factors |
| المشرفين على المادة: | 0 (Autoantibodies) |
| تواريخ الأحداث: | Date Created: 20240410 Date Completed: 20240411 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC11004955 |
| PMID: | 38595246 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1671-167X |
|---|