تقرير
Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma.
| العنوان: | Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma. |
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| المؤلفون: | Mak LS; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, Hong Kong SAR, China.; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Li X; Department of Pathology, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Chan WYK; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Leung AWK; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Cheuk DKL; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Yuen LYP; Department of Pathology, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., So JCC; Department of Pathology, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Ha SY; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China., Liu APY; Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China.; Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. |
| المصدر: | Frontiers in oncology [Front Oncol] 2024 Mar 26; Vol. 14, pp. 1364199. Date of Electronic Publication: 2024 Mar 26 (Print Publication: 2024). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Introduction: Medulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents. However, therapy-related complications, such as therapy-related myeloid neoplasms (t-MNs), can arise, particularly in patients with genetic predisposition syndromes. This case report presents three pediatric cases of medulloblastoma with subsequent development of t-MNs, highlighting the potential role of genetic predisposition and the importance of surveillance for hematological abnormalities in long-term survivors. Case Presentation: We describe three cases of pediatric medulloblastoma who developed t-MNs after receiving chemotherapy, including alkylating agents. Two of the patients had underlying genetic predisposition syndromes ( TP53 pathologic variants). The latency period between initial diagnosis of medulloblastoma and the development of secondary cancer varied among the cases, ranging from 17 to 65 months. The three cases eventually succumbed from secondary malignancy, therapy-related complications and progression of primary disease, respectively. Conclusions: This report highlights the potential association between genetic predisposition syndromes and the development of therapy-related myeloid neoplasms in pediatric medulloblastoma survivors. It underscores the importance of surveillance for hematological abnormalities among such patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Mak, Li, Chan, Leung, Cheuk, Yuen, So, Ha and Liu.) |
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| فهرسة مساهمة: | Keywords: Li-Fraumeni syndrome; alkylating agent; case report; chemotherapy; genetic predisposition; medulloblastoma (MB); therapy-related myelodysplastic syndrome/acute myeloid leukemia |
| تواريخ الأحداث: | Date Created: 20240410 Latest Revision: 20240411 |
| رمز التحديث: | 20240411 |
| مُعرف محوري في PubMed: | PMC11002154 |
| DOI: | 10.3389/fonc.2024.1364199 |
| PMID: | 38595820 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2234-943X |
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| DOI: | 10.3389/fonc.2024.1364199 |