دورية أكاديمية
Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α-Amanitin.
| العنوان: | Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α-Amanitin. |
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| المؤلفون: | Chao TH; Department of Chemistry, BioScience Research Collaborative, Rice University, Houston, Texas 77005, United States., Renata H; Department of Chemistry, BioScience Research Collaborative, Rice University, Houston, Texas 77005, United States. |
| المصدر: | Organic letters [Org Lett] 2024 Apr 19; Vol. 26 (15), pp. 3263-3266. Date of Electronic Publication: 2024 Apr 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1999- |
| مواضيع طبية MeSH: | Alpha-Amanitin*/chemistry , Amanitins*/pharmacology, Isoleucine ; RNA Polymerase II/chemistry ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism |
| مستخلص: | The ability of α-amanitin to potently inhibit RNA polymerase II (RNAP II) has elicited further research into its use as a novel payload for antibody-drug conjugates. Despite this promise, the de novo synthesis of α-amanitin is still a major challenge as it possesses an unusual bicyclic octapeptide structure that contains several oxidized amino acids, most notably 4,5-dihydroxy-l-isoleucine. Here, we report a concise chemoenzymatic synthesis of this key amino acid residue, which features two regioselective and diastereoselective enzymatic C-H oxidations on l-isoleucine. |
| المشرفين على المادة: | 0 (Alpha-Amanitin) 0 (Amanitins) 04Y7590D77 (Isoleucine) EC 2.7.7.- (RNA Polymerase II) |
| تواريخ الأحداث: | Date Created: 20240410 Date Completed: 20240422 Latest Revision: 20240422 |
| رمز التحديث: | 20240422 |
| DOI: | 10.1021/acs.orglett.4c00901 |
| PMID: | 38598422 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1523-7052 |
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| DOI: | 10.1021/acs.orglett.4c00901 |