دورية أكاديمية
Icodextrin-induced acute generalized exanthematous pustulosis in a patient with peritoneal dialysis.
| العنوان: | Icodextrin-induced acute generalized exanthematous pustulosis in a patient with peritoneal dialysis. |
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| المؤلفون: | Liu CH; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Chen CC; Division of Nephrology, Department of Medicine, Tri-Service General Hospital SongShan Branch, National Defense Medical Center, Taipei, Taiwan., Sung CC; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. |
| المصدر: | Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2024 Jul; Vol. 29 (7), pp. 442-445. Date of Electronic Publication: 2024 Apr 10. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9615568 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1797 (Electronic) Linking ISSN: 13205358 NLM ISO Abbreviation: Nephrology (Carlton) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Carlton, Vic., Australia : Blackwell Science, |
| مواضيع طبية MeSH: | Icodextrin* , Acute Generalized Exanthematous Pustulosis*/etiology , Acute Generalized Exanthematous Pustulosis*/diagnosis , Dialysis Solutions*/adverse effects , Peritoneal Dialysis*, Humans ; Female ; Adult ; Treatment Outcome ; Glucans/adverse effects ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/complications ; Glucose ; Biopsy ; Skin/pathology ; Skin/drug effects |
| مستخلص: | Icodextrin has been widely prescribed for peritoneal dialysis (PD) patients with inadequate ultrafiltration, but icodextrin induced acute generalized exanthematous pustulosis (AGEP) has been not well recognized in clinical practice. We described a young-aged female with IgA nephropathy and end stage kidney disease under continuous automated peritoneal dialysis. She developed skin erythema with exfoliation over the groin 7th day after initiation of icodextrin based PD dialysate. Initially, her scaling skin lesion with pinhead-sized pustules affected the bilateral inguinal folds, and then it extended to general trunk accompanied by pruritus. She was admitted because of deterioration of skin lesion on 14th day of icodextrin exposure. She was afebrile and physical examination was notable for widespread erythematous papules with pruritus extending over her groins and trunk. Pertinent laboratory examination showed leukocytosis of 18 970 cells/μL with neutrophile count of 17 642 cells/μL (92.3%), and c-reactive-protein: 3.39 mg/dL. Skin biopsy revealed multifocal sub corneal abscess with papillary dermal edema, and upper-dermal neutrophilia with perivascular accentuation, consistent with the diagnosis of AGEP. After discontinuation of PD, she underwent temporary high-flux haemodialysis with treatment of steroid and antihistamine. Her dermatologic lesion resolved without any skin sequalae completely within 4 days, and she underwent icodextrin-free peritoneal dialysis at 17th day. This case highlighted the fact that icodextrin-induced AGEP should be early recognized to avoid inappropriate management. (© 2024 Asian Pacific Society of Nephrology.) |
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| فهرسة مساهمة: | Keywords: acute generalized exanthematous pustulosis; icodextrin; peritoneal dialysis; skin rash |
| المشرفين على المادة: | 2NX48Z0A9G (Icodextrin) 0 (Dialysis Solutions) 0 (Glucans) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20240410 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1111/nep.14302 |
| PMID: | 38599621 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1797 |
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| DOI: | 10.1111/nep.14302 |