دورية أكاديمية
أعرض في EDS

Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.

التفاصيل البيبلوغرافية
العنوان: Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.
المؤلفون: Giron LB; The Wistar Institute, Philadelphia, PA, USA., Liu Q; The Wistar Institute, Philadelphia, PA, USA., Adeniji OS; The Wistar Institute, Philadelphia, PA, USA., Yin X; The Wistar Institute, Philadelphia, PA, USA., Kannan T; The Wistar Institute, Philadelphia, PA, USA., Ding J; The Wistar Institute, Philadelphia, PA, USA., Lu DY; The Wistar Institute, Philadelphia, PA, USA.; Cornell University, New York, NY, USA., Langan S; Johns Hopkins University, Baltimore, MD, USA., Zhang J; Johns Hopkins University, Baltimore, MD, USA., Azevedo JLLC; The Wistar Institute, Philadelphia, PA, USA., Li SH; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shalygin S; University of Georgia, Athens, GA, USA., Azadi P; University of Georgia, Athens, GA, USA., Hanna DB; Albert Einstein College of Medicine, Bronx, NY, USA., Ofotokun I; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Lazar J; SUNY Downstate Health Sciences University, New York, NY, USA., Fischl MA; Division of Infectious Disease, Department of Medicine, University of Miami, Miami, FL, USA., Haberlen S; Johns Hopkins University, Baltimore, MD, USA., Macatangay B; University of Pittsburgh, Pittsburgh, PA, USA., Adimora AA; University of North Carolina, Chapel Hill, NC, USA., Jamieson BD; University of California, Los Angeles, Los Angeles, CA, USA., Rinaldo C; University of Pittsburgh, Pittsburgh, PA, USA., Merenstein D; Georgetown University Medical Center, Washington, DC, USA., Roan NR; Gladstone Institutes, San Francisco, CA, USA.; University of California San Francisco, San Francisco, CA, USA., Kutsch O; University of Alabama at Birmingham, Birmingham, AL, USA., Gange S; Johns Hopkins University, Baltimore, MD, USA., Wolinsky SM; Northwestern University, Chicago, IL, USA., Witt MD; Lundquist Institute of Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA., Post WS; Johns Hopkins University, Baltimore, MD, USA., Kossenkov A; The Wistar Institute, Philadelphia, PA, USA., Landay AL; Rush University, Chicago, IL, USA., Frank I; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tien PC; University of California San Francisco, San Francisco, CA, USA., Gross R; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Brown TT; Johns Hopkins University, Baltimore, MD, USA., Abdel-Mohsen M; The Wistar Institute, Philadelphia, PA, USA. mmohsen@Wistar.org.
المصدر: Nature communications [Nat Commun] 2024 Apr 10; Vol. 15 (1), pp. 3035. Date of Electronic Publication: 2024 Apr 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: HIV Infections* , Aging, Premature*, Male ; Humans ; Female ; Immunoglobulin G ; Cross-Sectional Studies ; Aging ; Inflammation/complications ; Polysaccharides
مستخلص: People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH.
(© 2024. The Author(s).)
التعليقات: Update of: bioRxiv. 2023 Dec 31:2023.08.09.551369. doi: 10.1101/2023.08.09.551369. (PMID: 37609144)
References: PLoS One. 2012;7(9):e45821. (PMID: 23029261)
EBioMedicine. 2022 Apr;78:103957. (PMID: 35334306)
Arthritis Rheum. 2008 Oct;58(10):3081-9. (PMID: 18821684)
Am J Public Health. 2006 Jun;96(6):1020-7. (PMID: 16670218)
Glycobiology. 2010 Aug;20(8):959-69. (PMID: 20356825)
Clin Cancer Res. 2016 Jun 15;22(12):3078-86. (PMID: 26831718)
J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. (PMID: 26825179)
Front Cell Dev Biol. 2021 Jan 28;9:623175. (PMID: 33585480)
J Proteomics. 2022 Sep 30;268:104717. (PMID: 36084919)
Sci Transl Med. 2015 Sep 2;7(303):303ra140. (PMID: 26333936)
Theranostics. 2017 Feb 23;7(4):962-973. (PMID: 28382168)
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. (PMID: 24833586)
J Infect Dis. 2020 Nov 13;222(12):2093-2102. (PMID: 32060529)
Methods Mol Biol. 2022;2410:229-263. (PMID: 34914050)
Nat Immunol. 2019 Feb;20(2):163-172. (PMID: 30643263)
PLoS One. 2023 Apr 20;18(4):e0284838. (PMID: 37079606)
Lancet. 2013 Jun 15;381(9883):2109-17. (PMID: 23541541)
Biochim Biophys Acta. 2016 Aug;1860(8):1716-27. (PMID: 26968461)
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26. (PMID: 26658771)
J Am Heart Assoc. 2014 Sep 23;3(5):e001221. (PMID: 25249300)
Commun Biol. 2023 Mar 23;6(1):312. (PMID: 36959410)
Clin Diagn Lab Immunol. 2005 Sep;12(9):1013-9. (PMID: 16148165)
Diabetologia. 2017 Dec;60(12):2352-2360. (PMID: 28905229)
JCI Insight. 2017 Feb 23;2(4):e89703. (PMID: 28239652)
EBioMedicine. 2020 Sep;59:102945. (PMID: 32827942)
Exp Suppl. 2021;112:137-172. (PMID: 34687009)
J Biol Chem. 2012 May 4;287(19):15966-80. (PMID: 22403397)
Diabetes Care. 2020 Mar;43(3):661-668. (PMID: 31915204)
Anal Bioanal Chem. 2017 Jul;409(19):4483-4505. (PMID: 28585084)
Diagnostics (Basel). 2023 Mar 07;13(6):. (PMID: 36980324)
Front Immunol. 2021 Jun 09;12:686240. (PMID: 34177935)
Ann Transl Med. 2020 Mar;8(6):289. (PMID: 32355733)
Aging (Albany NY). 2017 Aug 2;9(8):1867-1884. (PMID: 28768895)
J Proteome Res. 2013 Sep 6;12(9):4046-55. (PMID: 23855414)
J Clin Immunol. 2010 May;30 Suppl 1:S9-14. (PMID: 20480216)
J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):777-8. (PMID: 24325897)
Mol Immunol. 2007 May;44(12):3122-31. (PMID: 17379311)
J Exp Med. 2007 Jan 22;204(1):11-5. (PMID: 17227911)
Mol Cell Proteomics. 2011 Oct;10(10):M111.010090. (PMID: 21653738)
Nat Med. 1995 Mar;1(3):237-43. (PMID: 7585040)
Dis Markers. 2008;25(4-5):267-78. (PMID: 19126970)
Front Cell Dev Biol. 2022 Dec 22;10:982609. (PMID: 36619858)
Electrophoresis. 2017 Jul;38(13-14):1788-1799. (PMID: 28426178)
Oncotarget. 2017 Oct 16;8(55):93338-93348. (PMID: 29212153)
Clin Endocrinol (Oxf). 1993 Oct;39(4):409-15. (PMID: 8287567)
Circulation. 2019 Dec 10;140(24):2005-2018. (PMID: 31597453)
Ageing Res Rev. 2013 Mar;12(2):685-98. (PMID: 22353383)
Cell. 2021 Jun 24;184(13):3573-3587.e29. (PMID: 34062119)
J Immunol Methods. 2011 Mar 7;366(1-2):8-19. (PMID: 21192942)
Nat Aging. 2021 Jul;1:598-615. (PMID: 34888528)
Exp Suppl. 2021;112:341-361. (PMID: 34687016)
Nat Biotechnol. 2008 Dec;26(12):1367-72. (PMID: 19029910)
Diabetes Care. 2022 Nov 1;45(11):2729-2736. (PMID: 36174116)
Anal Chim Acta. 2017 Feb 8;953:79-86. (PMID: 28010746)
Oncotarget. 2016 Feb 16;7(7):7455-68. (PMID: 26840264)
Epidemiology. 1998 Mar;9(2):117-25. (PMID: 9504278)
J Proteome Res. 2006 Jul;5(7):1626-35. (PMID: 16823970)
Aging Cell. 2006 Apr;5(2):187-95. (PMID: 16626397)
J Proteomics. 2012 Jun 6;75(10):2824-34. (PMID: 22365975)
Clin Exp Immunol. 2017 Jan;187(1):44-52. (PMID: 27198731)
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19571-8. (PMID: 19036920)
PLoS One. 2010 Sep 07;5(9):e12566. (PMID: 20830288)
Ann N Y Acad Sci. 2012 Apr;1253:16-36. (PMID: 22524423)
Int J Environ Res Public Health. 2022 Feb 18;19(4):. (PMID: 35206544)
Sci Adv. 2020 Feb 19;6(8):eaax0301. (PMID: 32128391)
Arthritis Rheum. 2010 Aug;62(8):2239-48. (PMID: 20506563)
Cell Rep. 2022 Dec 13;41(11):111799. (PMID: 36493786)
Curr Opin HIV AIDS. 2010 Nov;5(6):498-503. (PMID: 20978393)
Science. 2021 Feb 26;371(6532):. (PMID: 33361116)
J Immunol Methods. 2015 Feb;417:34-44. (PMID: 25523925)
Science. 2008 Apr 18;320(5874):373-6. (PMID: 18420934)
J Leukoc Biol. 2018 Sep;104(3):461-471. (PMID: 29633346)
Am J Epidemiol. 1987 Aug;126(2):310-8. (PMID: 3300281)
Cells. 2016 Nov 29;5(4):. (PMID: 27916834)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Front Immunol. 2023 Mar 14;14:981861. (PMID: 36999031)
Curr HIV/AIDS Rep. 2019 Apr;16(2):151-168. (PMID: 30707400)
Elife. 2014 Sep 03;3:e04066. (PMID: 25187624)
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7. (PMID: 7568133)
J Proteome Res. 2009 Feb;8(2):694-701. (PMID: 19035662)
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):637-648. (PMID: 29055820)
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8433-7. (PMID: 17485663)
EBioMedicine. 2022 Jul;81:104101. (PMID: 35773089)
Cancer Res. 2010 Jun 1;70(11):4481-9. (PMID: 20484044)
Science. 2006 Aug 4;313(5787):670-3. (PMID: 16888140)
Nat Rev Immunol. 2010 May;10(5):301-16. (PMID: 20414204)
Ann Rheum Dis. 2015 Jan;74(1):234-41. (PMID: 24106048)
N Engl J Med. 2014 Mar 20;370(12):1101-10. (PMID: 24401022)
Nat Med. 2012 Sep;18(9):1401-6. (PMID: 22922409)
Cell Res. 2016 Aug;26(8):963-6. (PMID: 27364686)
J Clin Invest. 2013 May;123(5):2183-92. (PMID: 23563315)
Nat Rev Cancer. 2012 Mar 22;12(4):278-87. (PMID: 22437872)
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9770-5. (PMID: 17522256)
Aging (Albany NY). 2016 Jul;8(7):1294-315. (PMID: 27391570)
Glycobiology. 2021 May 3;31(4):410-424. (PMID: 33135055)
Eur J Immunol. 2022 Jun;52(6):946-957. (PMID: 35307819)
iScience. 2022 Feb 10;25(3):103897. (PMID: 35243255)
Clin Chim Acta. 2022 Oct 1;535:30-45. (PMID: 35970404)
Gastroenterology. 2018 Apr;154(5):1320-1333.e10. (PMID: 29309774)
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. (PMID: 25733881)
Ann Intern Med. 2014 Apr 1;160(7):458-67. (PMID: 24687069)
Nat Rev Immunol. 2018 Jan;18(1):46-61. (PMID: 29063907)
J Mol Biol. 2014 Sep 9;426(18):3166-3179. (PMID: 25036289)
Blood. 2021 Oct 21;138(16):1481-1489. (PMID: 34315173)
J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):779-89. (PMID: 24325898)
Curr Opin Immunol. 2016 Jun;40:78-87. (PMID: 27038127)
Blood. 2010 Sep 9;116(10):1698-704. (PMID: 20516366)
J Allergy Clin Immunol. 2014 Mar;133(3):853-63.e5. (PMID: 24210883)
Nat Immunol. 2021 Jan;22(1):67-73. (PMID: 33169014)
J Immunol Methods. 2019 Oct;473:112630. (PMID: 31301278)
معلومات مُعتمدة: R01 AG062383 United States AG NIA NIH HHS; U01 HL146245 United States HL NHLBI NIH HHS; R01 DK123733 United States DK NIDDK NIH HHS; P30 CA010815 United States CA NCI NIH HHS; U01 HL146208 United States HL NHLBI NIH HHS; KL2 TR001432 United States TR NCATS NIH HHS; U01 HL146192 United States HL NHLBI NIH HHS; P30 AI045008 United States AI NIAID NIH HHS; U01 HL146242 United States HL NHLBI NIH HHS; TL1 TR001431 United States TR NCATS NIH HHS; R50 CA211199 United States CA NCI NIH HHS; R01 HL095129 United States HL NHLBI NIH HHS; R01 NS117458 United States NS NINDS NIH HHS; R21 AI170166 United States AI NIAID NIH HHS; R01 AI165079 United States AI NIAID NIH HHS; U01 HL146194 United States HL NHLBI NIH HHS; U01 HL146241 United States HL NHLBI NIH HHS; P30 AI027767 United States AI NIAID NIH HHS; P30 AI050409 United States AI NIAID NIH HHS; U01 HL146333 United States HL NHLBI NIH HHS; U01 HL146205 United States HL NHLBI NIH HHS; P30 MH116867 United States MH NIMH NIH HHS; UL1 TR001409 United States TR NCATS NIH HHS; K24 AI120834 United States AI NIAID NIH HHS; P30 AI073961 United States AI NIAID NIH HHS; U01 HL146201 United States HL NHLBI NIH HHS; U01 HL146193 United States HL NHLBI NIH HHS; R24 GM137782 United States GM NIGMS NIH HHS; U01 HL146204 United States HL NHLBI NIH HHS; U01 HL146202 United States HL NHLBI NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS; UL1 TR000004 United States TR NCATS NIH HHS; U01 HL146240 United States HL NHLBI NIH HHS; U01 HL146203 United States HL NHLBI NIH HHS; UL1 TR003098 United States TR NCATS NIH HHS; P30 AI050410 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Immunoglobulin G)
0 (Polysaccharides)
تواريخ الأحداث: Date Created: 20240410 Date Completed: 20240412 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11006954
DOI: 10.1038/s41467-024-47279-4
PMID: 38600088
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-47279-4