دورية أكاديمية
Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver grafts.
| العنوان: | Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver grafts. |
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| المؤلفون: | Wang S; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Lin X; Department of Thyroid and Breast Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China., Tang Y; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Liang Y; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Zhang M; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Xie Z; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Guo Y; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Dong Y; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Zhao Q; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Guo Z; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Wang D; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., He X; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Ju W; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China., Chen M; Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, People's Republic of China.; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, People's Republic of China. |
| المصدر: | Clinical and molecular hepatology [Clin Mol Hepatol] 2024 Jul; Vol. 30 (3), pp. 421-435. Date of Electronic Publication: 2024 Apr 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Korea : Korean Association for the Study of the Liver |
| مواضيع طبية MeSH: | Liver Transplantation*, Humans ; Male ; Female ; Middle Aged ; Prognosis ; Liver/pathology ; Liver/metabolism ; Adult ; Interleukins/genetics ; Interleukins/metabolism ; Transcriptome ; Pyroptosis ; Killer Cells, Natural/metabolism ; Graft Survival ; Tissue Donors ; Propensity Score |
| مستخلص: | Background/aims: The shortage of donor liver hinders the development of liver transplantation. This study aimed to clarify the poor outcomes of functionally marginal liver grafts (FMLs) and provide evidence for the improvement of ischemia-free liver transplantation (IFLT) after FML transplantation. Methods: Propensity score matching was used to control for confounding factors. The outcomes of the control group and FML group were compared to demonstrate the negative impact of FMLs on liver transplantation patients. We compared the clinical improvements of the different surgical types. To elucidate the underlying mechanism, we conducted bioinformatic analysis based on transcriptome and single-cell profiles. Results: FMLs had a significantly greater hazard ratio (HR: 1.969, P=0.018) than did other marginal livers. A worse 90-day survival (Mortality: 12.3% vs. 5.0%, P=0.007) was observed in patients who underwent FML transplantation. Patients who received FMLs had a significant improvement in overall survival after IFLT (Mortality: 10.4% vs 31.3%, P=0.006). Pyroptosis and inflammation were inhibited in patients who underwent IFLT. The infiltration of natural killer cells was lower in liver grafts from these patients. Bulk transcriptome profiles revealed a positive relationship between IL-32 and Caspase 1 (R=0.73, P=0.01) and between IL-32 and Gasdermin D (R=0.84, P=0.0012). Conclusion: FML is a more important negative prognostic parameter than other marginal liver parameters. IFLT might ameliorate liver injury in FMLs by inhibiting the infiltration of NK cells, consequently leading to the abortion of IL-32, which drives pyroptosis in monocytes and macrophages. |
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| معلومات مُعتمدة: | 81770410 National Natural Science Foundation of China; 2020A1515011557 Guangdong Basic and Applied Basic Research Foundation; 2020A1515010903 Guangdong Basic and Applied Basic Research Foundation; 2020B1212060026 Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology; 2020A0505020003 Guangdong Provincial International Cooperation Base of Science and Technology; 2019JYJH12 China organ transplantation development foundation |
| فهرسة مساهمة: | Keywords: Ischemia-free liver transplantation; Liver transplantation; Marginal liver grafts; Normothermic machine perfusion; Static cold storage; Transplantation immunology |
| المشرفين على المادة: | 0 (Interleukins) |
| تواريخ الأحداث: | Date Created: 20240411 Date Completed: 20240719 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| مُعرف محوري في PubMed: | PMC11261232 |
| DOI: | 10.3350/cmh.2024.0139 |
| PMID: | 38600871 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2287-285X |
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| DOI: | 10.3350/cmh.2024.0139 |