Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review.

التفاصيل البيبلوغرافية
العنوان:	Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review.
المؤلفون:	Uijterwijk BA; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. basuijterwijk@live.nl.; Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands. basuijterwijk@live.nl.; Cancer Center Amsterdam, Amsterdam, The Netherlands. basuijterwijk@live.nl., Lemmers DH; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy.; Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Fusai GK; Department of Surgery, Royal Free London NHS Foundation Trust, London, UK., Zerbi A; Department of Biomedical Sciences, Italy and Pancreatic Surgery, Humanitas University, IRCCS Humanitas Research Hospital, Pieve Emanuele, Rozzano, Italy., Salvia R; Department of General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., Sparrelid E; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden., White S; Department of Surgery, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK., Björnsson B; Department of Surgery in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Mavroeidis VK; Department of Academic Surgery, The Royal Marsden Hospital, London, UK.; Department of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Roberts KJ; Faculty of Medicine, University of Birmingham, Birmingham, UK., Mazzola M; Division of Oncologic and Mini-Invasive General Surgery, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Cabús SS; Department of Surgery, Hospital de Sant Pau, Barcelona, Spain., Soonawalla Z; Department of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Korkolis D; Department of Surgery, Hellenic Anticancer Hospital 'Saint Savvas', Athens, Greece., Serradilla M; Department of Surgery, Miguel Servet University Hospital, Zaragoza, Spain., Pessaux P; Hepatobiliary and Pancreatic Surgical Unit, Nouvel Hôpital Civil (NHC), Strasbourg, France., Luyer M; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Mowbray N; Department of Surgery, Morriston Hospital, Swansea, UK., Ielpo B; Department of Surgery, Hospital del Mar, Barcelona, Spain., Mazzotta A; Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris, France., Kleeff J; Department of Surgery, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany., Boggi U; Department of Surgery, Pisa University Hospital, Pisa, Italy., Muñoz MAS; Department of Surgery, University Hospital Virgen de la Victoria, Malaga, Spain., Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Duke-National University of Singapore, Singapore, Singapore., Andreotti E; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy., Wilmink H; Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Ghidini M; Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Zaniboni A; Department of Medical Oncology, Fondazione Poliambulanza, Brescia, Italy., Verbeke C; Department of Pathology, University of Oslo, Oslo University Hospital, Oslo, Norway., Adsay V; Department of Pathology, Koç University Hospital and Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey., Bianchi D; Department of Pathology, Fondazione Poliambulanza, Brescia, Italy., Besselink MG; Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands., Abu Hilal M; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. abuhilal9@gmail.com.
مؤلفون مشاركون:	International Study Group on Non-Pancreatic Periampullary Cancer (ISGACA)
المصدر:	Annals of surgical oncology [Ann Surg Oncol] 2024 Jul; Vol. 31 (7), pp. 4654-4664. Date of Electronic Publication: 2024 Apr 11.
نوع المنشور:	Systematic Review; Journal Article; Multicenter Study
اللغة:	English
بيانات الدورية:	Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994-
مواضيع طبية MeSH:	Lymphatic Metastasis* , Ampulla of Vater/pathology , Ampulla of Vater/surgery , Pancreaticoduodenectomy* , Common Bile Duct Neoplasms/pathology , Common Bile Duct Neoplasms/surgery , Duodenal Neoplasms/pathology , Duodenal Neoplasms/surgery , Pancreatic Neoplasms/surgery , Pancreatic Neoplasms/pathology , Adenocarcinoma/surgery , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Lymph Node Excision, Humans ; Retrospective Studies ; Male ; Female ; Cholangiocarcinoma/surgery ; Cholangiocarcinoma/pathology ; Aged ; Middle Aged ; Prognosis ; Follow-Up Studies ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/secondary
مستخلص:	Background: Standard lymphadenectomy for pancreatoduodenectomy is defined for pancreatic ductal adenocarcinoma and adopted for patients with non-pancreatic periampullary cancer (NPPC), ampullary adenocarcinoma (AAC), distal cholangiocarcinoma (dCCA), or duodenal adenocarcinoma (DAC). This study aimed to compare the patterns of lymph node metastases among the different NPPCs in a large series and in a systematic review to guide the discussion on surgical lymphadenectomy and pathology assessment. Methods: This retrospective cohort study included patients after pancreatoduodenectomy for NPPC with at least one lymph node metastasis (2010-2021) from 24 centers in nine countries. The primary outcome was identification of lymph node stations affected in case of a lymph node metastasis per NPPC. A separate systematic review included studies on lymph node metastases patterns of AAC, dCCA, and DAC. Results: The study included 2367 patients, of whom 1535 had AAC, 616 had dCCA, and 216 had DAC. More patients with pancreatobiliary type AAC had one or more lymph node metastasis (67.2% vs 44.8%; P < 0.001) compared with intestinal-type, but no differences in metastasis pattern were observed. Stations 13 and 17 were most frequently involved (95%, 94%, and 90%). Whereas dCCA metastasized more frequently to station 12 (13.0% vs 6.4% and 7.0%, P = 0.005), DAC metastasized more frequently to stations 6 (5.0% vs 0% and 2.7%; P < 0.001) and 14 (17.0% vs 8.4% and 11.7%, P = 0.015). Conclusion: This study is the first to comprehensively demonstrate the differences and similarities in lymph node metastases spread among NPPCs, to identify the existing research gaps, and to underscore the importance of standardized lymphadenectomy and pathologic assessment for AAC, dCCA, and DAC. (© 2024. The Author(s).)
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فهرسة مساهمة:	Investigator: G Nappo; P Ghorbani; G Malleo; F Lancelotti; N Napoli; S Robinson; K Khalil; AR Val; MCM Mortimer; B Al-Sarireh; YX Koh; R Bhogal; A Serrablo; B Gayet; K Johansen; M Ramaekers; A Giani
تواريخ الأحداث:	Date Created: 20240411 Date Completed: 20240613 Latest Revision: 20240613
رمز التحديث:	20240614
مُعرف محوري في PubMed:	PMC11164734
DOI:	10.1245/s10434-024-15213-z
PMID:	38602578
قاعدة البيانات:	MEDLINE

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تدمد:	1534-4681
DOI:	10.1245/s10434-024-15213-z