دورية أكاديمية
أعرض في EDS

Stress during pregnancy and fetal serum BDNF in cord blood at birth.

التفاصيل البيبلوغرافية
العنوان: Stress during pregnancy and fetal serum BDNF in cord blood at birth.
المؤلفون: Lamadé EK; Department of Psychiatry and Psychotherapy, Research-group Stress-related disorders, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: eva.lamade@zi-mannheim.de., Pedraz-Petrozzi B; Department of Psychiatry and Psychotherapy, Research-group Stress-related disorders, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: bruno.pedrazpetrozzi@zi-mannheim.de., Lindner O; Center for Child and Adolescent Health, Pediatrics, University Hospital of Freiburg, Freiburg 79106, Germany. Electronic address: ole.lindner@uniklinik-freiburg.de., Meininger P; Department of Gynecology and Obstetrics, Westpfalz-Klinikum, Kaiserslautern 67665, Germany. Electronic address: Pascal.Meininger@marienhaus.de., Coenen M; Institute for Medical Information Processing, Biometry and Epidemiology - IBE, Chair of Public Health and Health Services Research, Medical Faculty, LMU Munich, Munich, Germany; Pettenkofer School of Public Health, Munich, Germany. Electronic address: coenen@ibe.med.uni-muenchen.de., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Stephanie.Witt@zi-mannheim.de., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Marcella.Rietschel@zi-mannheim.de., Dukal H; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Helene.Dukal@zi-mannheim.de., Gilles M; Department of Psychiatry and Psychotherapy, Research-group Stress-related disorders, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Maria.Gilles@zi-mannheim.de., Wudy SA; Laboratory for Translational Hormone Analytics, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany. Electronic address: Stefan.Wudy@paediat.med.uni-giessen.de., Hellweg R; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, Germany. Electronic address: rainer.hellweg@charite.de., Deuschle M; Department of Psychiatry and Psychotherapy, Research-group Stress-related disorders, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Michael.Deuschle@zi-mannheim.de.
المصدر: Psychoneuroendocrinology [Psychoneuroendocrinology] 2024 Jul; Vol. 165, pp. 107035. Date of Electronic Publication: 2024 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor*/blood , Brain-Derived Neurotrophic Factor*/metabolism , Fetal Blood*/chemistry , Fetal Blood*/metabolism , Stress, Psychological*/metabolism , Stress, Psychological*/blood , Depression*/blood , Depression*/metabolism, Humans ; Female ; Pregnancy ; Adult ; Infant, Newborn ; Pregnancy Complications/blood ; Hydrocortisone/blood ; Male ; Anxiety/metabolism ; Anxiety/blood ; Cesarean Section/statistics & numerical data ; Prenatal Exposure Delayed Effects/metabolism ; Prenatal Exposure Delayed Effects/blood
مستخلص: Introduction: Adverse environments during pregnancy impact neurodevelopment including cognitive abilities of the developing children. The mediating biological alterations are not fully understood. Maternal stress may impact the neurotrophic regulation of the offspring as early as in utero and at birth. Brain-derived neurotrophic factor (BDNF) is essential for neurodevelopment. Short-term higher levels of BDNF in mice upon stressors associate with lower BDNF later in life, which itself associates with depression in animals and humans. Stress including glucocorticoids may impact BDNF, but there is a lack of data at birth. This study investigated if stress near term associates with fetal BDNF at birth in humans.
Methods: Pregnant women near term who underwent primary cesarean sections (at 38.80±0.64 weeks), were included in this study (n=41). Stress at the end of pregnancy was assessed before the cesarean section by determining maternal depressive symptoms (EDPS), maternal state and trait anxiety (STAI-S and STAI-T), maternal prenatal distress (PDQ), stress over the past month (PSS), prenatal attachment to the offspring (PAI), maternal social support (F-Sozu), maternal early life stress (CTQ), socioeconomic status, and the glucocorticoids cortisol and cortisone (n=40) in amniotic fluid at birth. The association with fetal BDNF was analyzed. Cord blood serum of n=34 newborns at birth was analyzed for BDNF and newborn anthropometrics (weight, length and head circumference per gestational age at birth) were assessed. The association of fetal BDNF with anthropometrics at birth was analyzed.
Results: After a BDNF-outlier (>3 SD) was removed, higher fetal BDNF associated significantly with maternal depressive symptoms (r=0.398, p=0.022), with lower socioeconomic status as assessed by the average number of people per room in the household (r=0.526, p=0.002) and with borderline significance with net income per person in the household (r=-0.313, p=0.087) in the bivariate analyses. In multivariable analysis, BDNF stayed positively associated with maternal depressive symptoms (β=0.404, 95% CI [7.057, 306.041], p=0.041) and lower net income per person in the household (β=-0.562, 95% CI [-914.511, -60.523], p=0.027) when controlling for maternal age, maternal pre-pregnancy BMI, fetal sex and gestational age. Fetal BDNF did not associate with newborn anthropometrics with the outlier removed in bivariate analyses or in multivariable analyses when controlling for maternal BMI and fetal sex.
Conclusion: Maternal depressive symptoms and lower socioeconomic status associated with higher fetal BDNF when controlling for confounders. Fetal BDNF did not associate with newborn anthropometrics with the outlier removed. Further studies should investigate how early altered BDNF associate with the development and possibly psychopathology of the offspring.
Competing Interests: Declaration of Competing Interest Eva Kathrin Lamadé received the Seed Money for Research grant from the Central Institute of Mental Health.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Cord blood; Cortisol; Fetal BDNF; Pregnancy; Socioeconomic status; Stress
المشرفين على المادة: 0 (Brain-Derived Neurotrophic Factor)
7171WSG8A2 (BDNF protein, human)
WI4X0X7BPJ (Hydrocortisone)
تواريخ الأحداث: Date Created: 20240411 Date Completed: 20240529 Latest Revision: 20240606
رمز التحديث: 20240606
DOI: 10.1016/j.psyneuen.2024.107035
PMID: 38603892
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3360
DOI:10.1016/j.psyneuen.2024.107035