دورية أكاديمية
أعرض في EDS

Haematopoietic innate interleukin 17A production drives immunopathology in female mouse genital Chlamydia muridarum infection.

التفاصيل البيبلوغرافية
العنوان: Haematopoietic innate interleukin 17A production drives immunopathology in female mouse genital Chlamydia muridarum infection.
المؤلفون: Armitage CW; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.; Peter Goher Department of Immunobiology, Kings College London, London, UK., Bryan ER; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Trim L; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Palframan E; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Wager L; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Beagley KW; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Carey AJ; School of Biomedical Science and Centre for Immunology and Infection Control, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
المصدر: Scandinavian journal of immunology [Scand J Immunol] 2024 May; Vol. 99 (5), pp. e13359. Date of Electronic Publication: 2024 Jan 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3083 (Electronic) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Scientific Publications
Original Publication: Oslo, Universitetsforlaget.
مواضيع طبية MeSH: Chlamydia Infections* , Chlamydia muridarum* , Interleukin-17* , Reproductive Tract Infections*/pathology, Animals ; Female ; Mice ; Mice, Inbred C57BL
مستخلص: Chlamydia trachomatis infection is the leading cause of bacterial urogenital infection and has been demonstrated to drive inflammation and scarring of the reproductive tract. Recent studies have identified key triggers of proinflammatory adaptive immune responses driven by innate leukocytes and epithelia driving immunopathology. Utilizing chimeric mouse models, we investigated the definitive source and role of IL17 and IL17 signalling receptors during early Chlamydia muridarum infection of the female urogenital tract. Bone marrow transplants from wild-type (WT) and IL17A -/- mice to recipients demonstrated equivocal infection kinetics in the reproductive tract, but interestingly, adoptive transfer of IL17A -/- immune cells to WT recipients resulted in no infertility, suggesting a haematopoietic (as opposed to tissue) source of IL17 driving immunopathology. To further delineate the role of IL17 in immunopathology, we infected WT and IL17 receptor A (IL17RA) -/- female mice and observed a significant reduction in immunopathology in IL17RA -/- mice. WT bone marrow transplants to IL17RA -/- recipient mice prevented hydrosalpinx, suggesting signalling through IL17RA drives immunopathology. Furthermore, early chemical inhibition of IL17 signalling significantly reduced hydrosalpinx, suggesting IL17 acts as an innate driver of disease. Early during the infection, IL17 was produced by γδ T cells in the cervico-vagina, but more importantly, by neutrophils at the site of infertility in the oviducts. Taken together, these data suggest innate production of IL17 by haematopoietic leukocytes drives immunopathology in the epithelia during early C. muridarum infection of the female reproductive tract.
(© 2024 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.)
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معلومات مُعتمدة: National Health and Medical Research Council; APP1052464 National Health and Medical Research Council (NHMRC); APP1083314 National Health and Medical Research Council (NHMRC)
فهرسة مساهمة: Keywords: Chlamydia infection; infertility; interleukin 17A
المشرفين على المادة: 0 (Interleukin-17)
تواريخ الأحداث: Date Created: 20240412 Date Completed: 20240415 Latest Revision: 20240429
رمز التحديث: 20240429
DOI: 10.1111/sji.13359
PMID: 38605527
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-3083
DOI:10.1111/sji.13359