دورية أكاديمية
أعرض في EDS

Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study.

التفاصيل البيبلوغرافية
العنوان: Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study.
المؤلفون: Lewis DV; Department of Pediatrics (Neurology), Duke University Medical Center, Durham, North Carolina, USA., Voyvodic J; Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA., Shinnar S; Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA., Chan S; Department of Radiology, Harlem Hospital Center, Columbia University, New York, New York, USA., Bello JA; Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA., Moshé SL; Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, and Montefiore Medical Center, Bronx, New York, USA., Nordli DR Jr; Department of Pediatrics, Section of Child Neurology, University of Chicago, Chicago, Illinois, USA., Frank LM; Department of Neurology, Children's Hospital of the King's Daughters and Eastern Virginia Medical School, Norfolk, Virginia, USA., Pellock JM; Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA., Hesdorffer DC; Department of Epidemiology, G. H. Sergievsky Center, Columbia University, New York, New York, USA., Xu Y; Department of Pediatrics (Neurology), Duke University Medical Center, Durham, North Carolina, USA., Shinnar RC; Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA., Seinfeld S; Pediatric Epilepsy Program, Joe DiMaggio Children's Hospital, Hollywood, Florida, USA., Epstein LG; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Masur D; Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA., Gallentine W; Stanford University Lucile Packard Children's Hospital, Palo Alto, California, USA., Weiss E; Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA., Deng X; Biostatistics and International Epilepsy Consortium, Virginia Commonwealth University, Richmond, Virginia, USA., Sun S; Biostatistics and International Epilepsy Consortium, Virginia Commonwealth University, Richmond, Virginia, USA.
مؤلفون مشاركون: FEBSTAT Study Team
المصدر: Epilepsia [Epilepsia] 2024 Jun; Vol. 65 (6), pp. 1568-1580. Date of Electronic Publication: 2024 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Blackwell Science
Original Publication: Copenhagen : Munskgaard
مواضيع طبية MeSH: Hippocampus*/pathology , Hippocampus*/diagnostic imaging , Epilepsy, Temporal Lobe*/diagnostic imaging , Epilepsy, Temporal Lobe*/pathology , Sclerosis*/pathology , Status Epilepticus*/diagnostic imaging , Status Epilepticus*/pathology , Status Epilepticus*/etiology , Magnetic Resonance Imaging* , Seizures, Febrile*/pathology , Seizures, Febrile*/diagnostic imaging, Humans ; Male ; Female ; Infant ; Child, Preschool ; Child ; Follow-Up Studies ; Atrophy/pathology ; Hippocampal Sclerosis
مستخلص: Objective: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.
Methods: Acute magnetic resonance imaging (MRI) was obtained within a mean of 4.4 (SD = 5.5, median = 2.0) days after febrile status on >200 infants with follow-up MRI at approximately 1, 5, and 10 years. Hippocampal size, morphology, and T2 signal intensity were scored visually by neuroradiologists blinded to clinical details. Hippocampal volumetry provided quantitative measurement. Upon the occurrence of two or more unprovoked seizures, subjects were reassessed for epilepsy. Hippocampal volumes were normalized using total brain volumes.
Results: Fourteen of 22 subjects with acute hippocampal T2 hyperintensity returned for follow-up MRI, and 10 developed definite hippocampal sclerosis, which persisted through the 10-year follow-up. Hippocampi appearing normal initially remained normal on visual inspection. However, in subjects with normal-appearing hippocampi, volumetrics indicated that male, but not female, hippocampi were smaller than controls, but increasing hippocampal asymmetry was not seen following febrile status. Forty-four subjects developed epilepsy; six developed mesial temporal lobe epilepsy and, of the six, two had definite, two had equivocal, and two had no hippocampal sclerosis. Only one subject developed mesial temporal epilepsy without initial hyperintensity, and that subject had hippocampal malrotation. Ten-year cumulative incidence of all types of epilepsy, including mesial temporal epilepsy, was highest in subjects with initial T2 hyperintensity and lowest in those with normal signal and no other brain abnormalities.
Significance: Hippocampal T2 hyperintensity following febrile status epilepticus predicted hippocampal sclerosis and significant likelihood of mesial temporal lobe epilepsy. Normal hippocampal appearance in the acute postictal MRI was followed by maintained normal appearance, symmetric growth, and lower risk of epilepsy. Volumetric measurement detected mildly decreased hippocampal volume in males with febrile status.
(© 2024 International League Against Epilepsy.)
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معلومات مُعتمدة: R01 HD036867 United States HD NICHD NIH HHS; 43209 United States NS NINDS NIH HHS; R01 NS043209 United States NS NINDS NIH HHS; R37 NS043209 United States NS NINDS NIH HHS; Dana Foundation; 36867 National Institute of Child Health and Human Development; N01 HD023343 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: MRI volumetry; T2 signal intensity; febrile seizures; hippocampal malrotation
تواريخ الأحداث: Date Created: 20240412 Date Completed: 20240611 Latest Revision: 20240615
رمز التحديث: 20240615
مُعرف محوري في PubMed: PMC11166525
DOI: 10.1111/epi.17979
PMID: 38606600
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-1167
DOI:10.1111/epi.17979