دورية أكاديمية
Neuroprotective activity of Colocasia esculenta (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study.
| العنوان: | Neuroprotective activity of Colocasia esculenta (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study. |
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| المؤلفون: | Khazaal HT; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt., El-Sayed EK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt., Mansour YE; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt., Ibrahim RR; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt., Bishr M; Plant General Manager and Technical Director of the Arab Company for Pharmaceuticals and Medicinal, Plants, Cairo, Egypt., El Dib RA; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt., Soliman HSM; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo, Egypt.; PharmD program, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Alexandria, Egypt. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Apr 12, pp. 1-9. Date of Electronic Publication: 2024 Apr 12. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: | Colocasia esculenta (L.) Schott is a food crop with long history of use in treatment of various disorders including neurological diseases. The methanolic leaves extract (ME) and its n -butanol fraction ( n -BF) demonstrated significant in vivo neuroprotective activity in monosodium glutamate induced excitotoxicity in rats. Sixteen and fifteen polyphenolic compounds were identified in n -BF and ME, respectively, using HPLC. Phytochemical investigation of n -BF followed by 1D ( 1 H and 13 C NMR) spectroscopic analyses led to isolation and identification of daucosterol ( 1 ), thermopsoside ( 2 ) and chrysoeriol 7- O - β -D-neohesperidoside ( 3 ) for the first time from genus Colocasia , in addition to orientin ( 4 ). LC/MS/MRM analysis of fraction V obtained from n -BF revealed identification of 13 polyphenolic compounds. Molecular docking of isolated compounds confirmed binding of all compounds at the target pocket with higher energy than crystallised ligand. The current study evaluated and confirmed the mechanistic aspects of neuroprotective activity of C. esculenta leaves for the first time. |
| فهرسة مساهمة: | Keywords: Araceae; Colocasia esculenta (L.) Schott; excitotoxicity; molecular docking; neuroprotective; polyphenols |
| تواريخ الأحداث: | Date Created: 20240412 Latest Revision: 20240412 |
| رمز التحديث: | 20240412 |
| DOI: | 10.1080/14786419.2024.2340061 |
| PMID: | 38606753 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2024.2340061 |