دورية أكاديمية
Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study.
| العنوان: | Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study. |
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| المؤلفون: | Nobre DAB; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Moura MDG; Department of Dentistry, Centro Universitário Vale do Rio Verde - UNINCOR, Belo Horizonte, Brazil., de Arruda JAA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Felix FA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Diniz PB; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Duarte ECB; Department of Pathology, School of Medicine, Universidade de Brasília, Brasília, Brazil., Abreu LG; Department of Child and Adolescent Oral Health, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gomez RS; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Mesquita RA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |
| المصدر: | International journal of STD & AIDS [Int J STD AIDS] 2024 Jul; Vol. 35 (8), pp. 627-634. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dec. 2012- : London : Sage Original Publication: London, U.K. : Royal Society of Medicine Services, c1990- |
| مواضيع طبية MeSH: | Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage , Leukoplakia, Hairy*/drug therapy , Leukoplakia, Hairy*/virology , Herpesvirus 4, Human*/genetics , Herpesvirus 4, Human*/isolation & purification , Acyclovir*/therapeutic use , Acyclovir*/administration & dosage , Administration, Topical* , DNA, Viral*/analysis , Epstein-Barr Virus Infections*/drug therapy , Epstein-Barr Virus Infections*/virology, Humans ; Female ; Male ; Middle Aged ; Adult ; Podophyllin/therapeutic use ; Podophyllin/administration & dosage ; Treatment Outcome ; HIV Infections/drug therapy ; HIV Infections/virology ; Polymerase Chain Reaction ; Guanine/analogs & derivatives ; Guanine/therapeutic use ; Guanine/administration & dosage |
| مستخلص: | Background: This study evaluated the presence of Epstein-Barr virus type 1 (EBV-1) DNA in patients living with HIV, before and after three different topical therapy protocols for oral hairy leukoplakia (OHL). Methods: The sample consisted of five patients treated with topical solution of 25% podophyllin resin; six with 25% podophyllin resin plus 5% acyclovir cream; and four with 25% podophyllin resin plus 1% penciclovir cream. DNA was extracted from OHL scrapings and amplified by the PCR using specific primers for EBV-1 (EBNA-1). Results: Clinical healing of OHL lesions was observed across all treatment groups over time. At baseline, EBNA-1 was detected in all OHL lesions. After treatment, OHL samples from three patients treated with 25% podophyllin resin plus 5% acyclovir cream and from one patient treated with 25% podophyllin resin plus 1% penciclovir cream exhibited negative EBNA-1 viral gene encoding. Despite the clinical resolution of OHL, 11 patients (73.3%) showed EBNA-1 positivity immediately after the lesion disappeared. Three patients (20%) treated with podophyllin resin displayed both EBNA-1 positivity and a recurrence of OHL, in contrast to no recurrence in the other two groups. Conclusions: These findings suggest potential associations between treatment formulations, EBNA-1 persistence, and the recurrence of OHL lesions. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: Antiretroviral agent; human immunodeficiency virus; oral hairy leukoplakia; podophyllin; topical administration |
| المشرفين على المادة: | 0 (Antiviral Agents) X4HES1O11F (Acyclovir) 0 (DNA, Viral) 9000-55-9 (Podophyllin) 359HUE8FJC (penciclovir) 5Z93L87A1R (Guanine) |
| تواريخ الأحداث: | Date Created: 20240412 Date Completed: 20240727 Latest Revision: 20240727 |
| رمز التحديث: | 20240728 |
| DOI: | 10.1177/09564624241246298 |
| PMID: | 38606785 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-1052 |
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| DOI: | 10.1177/09564624241246298 |